《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (03): 231-232.

• 基础研究 • 上一篇    下一篇

脑外伤大鼠癫痫易感性的研究

邓亚仙;高宝勤;杨伟力   

  1. 首都医科大学附属北京天坛医院儿科，北京市 100050
  • 收稿日期:2008-12-03 出版日期:2009-03-01 发布日期:2009-03-01

Susceptibility of Epilepsy in Rat with Cerebral Trauma

DENG Ya-xian，GAO Bao-qin，YANG Wei-li   

  1. Department of Pediatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2008-12-03 Published:2009-03-01 Online:2009-03-01

PDF (PC)

被引次数

4

摘要： 目的 研究外伤后癫痫易感性的变化。方法 采用自由落体法建立大鼠急性脑外伤模型，描记脑电图，采用戊四氮腹腔注射制备癫痫模型，记录戊四氮最小致痫量。结果 大鼠脑外伤后脑电图δ、θ波段较健康大鼠增加，α波减少，δ、θ、α波相对功率值比较有显著性差异（P＜0.05）；大鼠脑损伤组致痫所需最小戊四氮量值小于健康大鼠对照组（P＜0.05）。结论 脑外伤后大鼠癫痫易感性增高。

关键词: 脑外伤, 癫痫, 脑电图, 戊四氮, 易感性

Abstract: Objective To explore the susceptibility of epilepsy in rat with cerebral trauma. Methods An impact-acceleration head injury model was established with rats. After trauma, the electroencephalograph was recorded. Epileptic model wad established by injecting pentylenetetrazol (PTZ) intraperitoneally and the dosage of PTZ was recorded. Results The wave of delta and theta increased after trauma, alpha and beta decreased and there was significant difference among the power of delta, theta and alpha (P＜0.05). The dosage of rats with cerebral trauma was less than that in normal rats (P＜0.05). Conclusion The susceptibility of epilepsy in rat with cerebral trauma increases.

Key words: traumatic brain injury, epilepsy, electroencephalograph (EEG), pentylenetetrazol (PTZ), susceptibility