《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (05): 479-480.

• 临床研究 • 上一篇    下一篇

高血压病患者动态动脉硬化指数与早期肾脏异常的关系

张威1a;王禹1a;赵宇1b   

  1. 1.解放军总医院,a.心血管内科;b.心电图室, 北京市 100853
  • 收稿日期:2009-03-06 修回日期:2009-05-07 出版日期:2009-05-01 发布日期:2009-05-01
  • 通讯作者: 王禹

Correlation between Ambulatory Arterial Stiffness Index and Renal Abnormalities in Primary Hypertension

ZHANG Wei, WANG Yu, ZHAO Yu   

  1. Department of Cardiology, General Hospital of PLA, Bejing 100853, China
  • Received:2009-03-06 Revised:2009-05-07 Published:2009-05-01 Online:2009-05-01

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摘要： 目的 探讨高血压病患者动态动脉硬化指数与早期肾脏损害征象之间的关系。方法 随机检测72例高血压病患者的动态动脉硬化指数（AASI）、动态血压、动态脉压，检测患者的肌酐、尿微量白蛋白，计算肾小球滤过率。按照患者的AASI分为两组：AASI低水平组（AASI≤0.51）40例，AASI高水平组（AASI＞0.51）32例。比较两组各参数指标的差别；并对各参数指标进行Pearson相关性分析和多因素Logistic回归分析。结果 与AASI低水平组相比，AASI高水平组尿微量白蛋白量增高(P<0.05)，肾小球滤过率明显降低(P<0.01)。单因素分析显示，AASI与尿微量白蛋白正相关（r=0.32, P<0.001），与肾小球滤过率呈负相关（r=0.44, P<0.001）。在校正了混杂因素后，AASI对早期肾脏功能损害的OR为2.18（P=0.008，95%CI：1.76～4.34）。结论 AASI增加与高血压早期肾损害相关。

关键词: 高血压病, 动态动脉硬化指数（AASI）, 肾损害

Abstract: Objective To investigate the relationship between ambulatory arterial stiffness index (AASI) derived from blood pressure monitoring and early signs of renal damage in patients with primary hypertension． Methods 74 primary hypertensive outpatients were divided into two groups according to their AASI values: normal AASI group (AASI≤0.51, n=40) and high AASI group (AASI>0.51, n=32). The urinary micro-albumin, glomerular filtration rates (GFR) were measured and compared. The relationship between AASI and micro-albumin, GFR were tested with Pearson correlation and multiple Logistic regression. Results Compared with those in the normal AASI group, the patients in high AASI group showed a higher level of urinary microalbumin (P<0.05) and a reduction in GFR (P<0.01). AASI was positively correlated with urinary microalbumin （r=0.32, P<0.001）, and negatively correlated with GFR （r=0.44, P<0.001）. After adjusting the potentially confounding variables, the odd ratio (OR) of AASI to renal damage was 2.18 （P=0.008，95%CI：1.76～4.34）. Conclusion The increase of AASI is associated with early signs of renal damage in patients with primary hypertension.

Key words: hypertension, ambulatory arterial stiffness index(AASI), renal damage