《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (06): 529-531.

• 基础研究 • 上一篇    下一篇

异体脱钙骨基质-利福平明胶复合材料治疗修复兔桡骨缺损的实验研究

冯会成;胡明;马远征;李宏伟   

  1. 解放军总医院第二附属医院骨科，北京市 100091
  • 收稿日期:2009-03-05 出版日期:2009-06-01 发布日期:2009-06-01

Experimental Study of Efficacy of a DBM-rifampicin Composite Graft in Healing of Segmental Radial Defect in Rabbits

FENG Hui-cheng, HU Ming, MA Yuan-zheng, et al   

  1. The 2nd Affiliated Hospital, PLA General Hospital, Beijing 100091, China
  • Received:2009-03-05 Published:2009-06-01 Online:2009-06-01

PDF (PC)

被引次数

4

摘要： 目的 研究异体脱钙骨基质（DBM）-利福平明胶复合体作为抗结核植骨复合材料，对兔桡骨缺损修复的能力及其缓释效果。方法 参考Urist操作方法制备兔同种异体DBM并与载有利福平的明胶复合体制备抗结核复合材料，通过标准兔桡骨缺损模型观察复合材料骨修复特性及利福平缓释效果。结果 异体DBM-利福平明胶复合材料能够有效修复骨缺损并达到药物缓释的目的。结论 异体DBM-利福平明胶复合材料具有良好的成骨活性和药物缓释效果，可作为临床植骨的缓释药物使用，其临床应用效果可望进一步研究。

关键词: 脱钙骨基质, 利福平, 抗痨, 复合材料

Abstract: Objective To evaluate the antibiotics release characteristic and osteogenesis ability of anti-tuberculosis composite graft by observing the healing effect of segmental radial defect in rabbits.Methods Rabbit decalcified bone matrix(DBM) was made under the method of Urist and was combined with rifampicin-gelatin solution. The antibiotics release characteristics were observed by PBS release test in vitro and K-B disc diffusion test in vivo. The osteogenesis ability was measured by critical radius bone defect of rabbit.Results It was detected in release test that the antibiotic releasing time could maintain at least 28 days in vivo and in vitro and the release ratio was 87%. The rabbit critical radius bone defect could be repaired by this anti-tuberculosis composite graft perfectly.Conclusion Good antibiotics release characteristics and bone formation ability showed during this anti-tuberculosis composite graft and it definitely could be used widely in further clinics.

Key words: decalcified bone matrix, rifampicin, anti-tuberculosis, composite graft