《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (06): 534-537.

• 基础研究 • 上一篇    下一篇

长期中等强度运动训练及依那普利对Thy-1肾炎慢性肾功能衰竭大鼠模型肾功能的影响

吴学敏1;谢欲晓1;孙启良1;上月正博2;佐藤德太郎2   

  1. 1.中日友好医院物理康复科，北京市 100029;2.日本东北大学大学院医学系研究科障害科学
  • 收稿日期:2009-04-16 出版日期:2009-06-01 发布日期:2009-06-01

Effect of Chronic Exercise Training and Enalapril on Renal Function in Thy-1-Crf

WU Xue-min, XIE Yu-xiao, SUN Qi-liang, et al   

  1. Dept. of Rehabilitation Medicine, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2009-04-16 Published:2009-06-01 Online:2009-06-01

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摘要： 目的 探讨运动训练及其与依那普利联合应用对肾功能的影响。方法 将Wistar大鼠在 5周龄时摘除一侧肾脏后，每周1次静脉注射Thy1抗体共4次, 制备Thy1肾炎模型。于6周龄时随机分为非运动组、中等强度运动训练组和运动训练加依那普利组。其中运动训练组所有动物进行跑台训练, 速度20 m/mim，60 min/d, 5 d/周。依那普利2 mg/kg·d腹腔内持续给药。结果 非运动组的血压和尿蛋白分泌明显增加。运动训练并没有抑制尿蛋白分泌和血肌酐的增加，肾小球硬化指数也有增大倾向。而运动训练加依那普利使血压明显下降和尿蛋白分泌明显减少，完全抑制运动对尿蛋白、血肌酐以及肾小球硬化指数的影响。结论 对于Thy1肾炎模型，中等强度运动训练保护肾功能的作用不明显。由于形成慢性肾功能衰竭的原发病不同，长期运动对肾功能的影响可能也不同，提示运动训练时与依那普利并用可能扩大运动的范围。

关键词: 运动训练, 依那普利, Thy1肾炎模型, 肾功能

Abstract: Objective To determine the renal effects of chronic exercise training and enalapril in uninephrectomized anti-Thy-1 nephritis Wistar rats (Thy-1-Crf). Methods 5-week-old Wistar rats were subjected to uninephrectomy. Anti-Thy-1 nephritis was induced by injecting 200 μg/kg OX-7 intravenously once a week for four times. They were divided into 3 groups: non exercise; moderate exercise with treadmill running(20 m/min, 0 grade-incline for 60 min); moderate exercise with an angiotensin converting enzyme(ACE) inhibitors, enalapril (2 mg/kg/day i.p.) for 8 weeks.Results Exercise did not suppress the increase in proteinuria in Thy-1-Crf. However, enalapril significantly decreased systolic blood pressure(SBP), urinary protein excretion(UpE), and index of glomerular sclerosis (IGS) in Thy-1-Crf. Conclusion The renal protective effects of moderate exercise in models of renal failure differ depending on the etiology of renal failure. It also suggests that enalapril can widen the acceptable range of exercise intensity in Thy-1-Crf.

Key words: exercise training, enalapril, anti-Thy-1 nephritis Wistar rats, renal function