《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (06): 538-540.

• 综述 • 上一篇    下一篇

神经元轴突因子对成鞘胶质细胞影响的研究进展

曹念1;彭利民1;杨柳扬1;刘运来2;姚忠祥2   

  1. 1.第三军医大学学员旅三队，重庆市 400038;2.第三军医大学组织胚胎学教研室，重庆市 400038
  • 收稿日期:2009-04-01 出版日期:2009-06-01 发布日期:2009-06-01
  • 通讯作者: 姚忠祥

Advance in Neuron Axonal Singnals on Ensheathing Glial Cells(review)

CAO Nian, PENG Li-min, YANG Liu-yang, et al   

  1. Squadron 3 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China
  • Received:2009-04-01 Published:2009-06-01 Online:2009-06-01

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摘要： 神经元轴突因子对中枢神经系统的髓鞘形成发挥重要作用。髓鞘形成受到正性和负性神经元轴突因子的共同调节。正神经元轴突因子包括神经调节素、神经细胞黏附因子、电活动、神经营养素等，具有促进成鞘胶质细胞增殖和髓鞘增厚的作用；负性神经元轴突因子包括L1蛋白、聚唾液酸-神经细胞黏附分子等，具有明显减少髓鞘形成的作用。本文简要介绍一些正性和负性神经元轴突因子及其部分作用机制。

关键词: 神经元轴突因子, 成鞘胶质细胞, 髓鞘形成, MAPK信号通路, 综述

Abstract: Neuron axonal signals play an important role in myelination of central nervous system. Myelination depends on a balance between the positive and negative neuron axonal signals. The positive signals, such as neuregulins (NRG), neuron cell adhesion molecule (NCAM), electrical activity and neurotrophins, have a function of promoting the proliferation and the myelination thickness of ensheathing glial cells, while the negative factors like the L1 protein, poly-sialic acid-neuron cell adhesion molecule (PSA-NCAM), will lead a marked decrease in myelination. Here，we mainly present some well-researched neuron axonal factors and their mechanism.

Key words: neuron axonal singnals, ensheathing glial cells, myelination, MAPK pathway, review