《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (06): 545-547.

• 综述 • 上一篇    下一篇

帕金森病伴抑郁的诊治分析

杨永秀1;潘冰2   

  1. 1. 浙江省杭州市第七人民医院老年康复中心， 浙江杭州市 310013;2. 浙江大学附属第二医院精神科，浙江杭州市 310009
  • 收稿日期:2009-02-19 出版日期:2009-06-01 发布日期:2009-06-01

Diagnosis and Treatment of Parkinson's Disease Following Depression(review)

YANG Yong-xiu, PAN Bing   

  1. Rehabilitation Center for Elderly, the 7th Hangzhou People's Hospital, Hangzhou 310013, Zhejiang, China
  • Received:2009-02-19 Published:2009-06-01 Online:2009-06-01

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摘要： 抑郁是帕金森病患者常见的精神症状，是影响帕金森病患者生活质量、增加致残率的重要因素。然而，由于重叠症状的存在以及认知功能的损害，对帕金森病伴抑郁做出正确的诊断还存在一定的困难，一些抑郁量表已被用来帮助诊断。三环类抗抑郁药以及新一代抗抑郁药，包括5-羟色胺（5-HT）再摄取抑制剂，5-HT、去甲肾上腺素（NE）再摄取抑制剂，选择性NE再摄取抑制剂已被用于改善帕金森病患者的抑郁症状并显示出一定的疗效，多巴胺受体激动剂也具有一定的抗抑郁作用。

关键词: 帕金森病, 抑郁, 抑郁量表, 抗抑郁药, 综述

Abstract: Depression is a common comorbid condition in Parkinson's disease (PD) and a major contributor to poor quality of life and disability. However, depression can be difficult to assess in patients with PD due to overlapping symptoms and difficulties in the assessment of depression in cognitively impaired patients, several rating scales have been used to assess depression in PD. Tricyclic and new selective antidepressants including serotonin and noradrenaline reuptake inhibitors, selective serotonin reuptake inhibitors, selective noradrenaline reuptake inhibitors appear to be effective in treating depression in PD. Clinical investigation indicate antidepressive effects in PD.

Key words: pakinson's disease, depression, depression rating scale, antidepressants, review