《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (07): 650-651.

• 临床研究 • 上一篇    下一篇

脑白质疏松症相关因素的多因素回归分析

彭超英;解恒革;李金梅   

  1. 解放军总医院干部诊疗科，北京市 100853
  • 收稿日期:2009-03-18 修回日期:2009-05-26 出版日期:2009-07-01 发布日期:2009-07-01

Related Factors of Leukoaraiosis: A Multi-Logistic Regression Analysis

PENG Chao-ying,XIE Heng-ge,LI Jin-mei   

  1. General Hospital of PLA, Beijing 100853, China
  • Received:2009-03-18 Revised:2009-05-26 Published:2009-07-01 Online:2009-07-01

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摘要： 目的 研究脑白质疏松症(LA)的发病危险因素。方法 回顾性调查480例曾行头颅CT或MRI检查的老年患者，分别进行单因素和多元Logistic回归分析。依据LA严重程度与年龄及高血压病史做等级相关分析。结果 脑白质疏松症的发生率为35%，LA组中患者年龄（t=3.243，P=0.0013）、高血压患者比例（χ2=9.8941，P=0.0017）均大于非LA组，糖尿病患者的比例小于非LA组（χ2=4.4193，P=0.0355）; Logistic回归分析结果显示年龄（OR=1.06，95%CI：1.027～1.103，P=0.0006）、高血压（OR=1.15，95% CI：1.065～1.236，P=0.0003）、糖尿病病史（OR=0.85，95% CI：0.726～0.994，P=0.0421）与LA的发生有相关性。等级相关分析显示,LA严重程度增加与年龄增长（r=0.1553，χ2=4.9701，P=0.5477)及高血压病程增加(r=-0.0758，χ2=1.9076，P=0.7527）均无相关性。结论 年龄和高血压病史是LA的独立发病危险因素，但LA的严重程度与年龄大小及高血压病史长短没有相关性。

关键词: 脑白质疏松症(LA), 危险因素, 年龄, 高血压病, 糖尿病

Abstract: Objective To study the related factors of leukoaraiosis (LA). Methods 480 elderly patients examined with cranial CT or MRI were investigated retrospectively. A single-factor and multi-Logistic regression analysis were performed. A rank correlation analysis was performed between the severity of LA and age as well as the course of hypertension. Results The prevalence of LA was 35%. The age (t=3.243，P=0.0013) and the incidence of hypertension (χ2=9.8941，P=0.0017) were higher in LA group than in non-LA group, the incidence of diabetic were lower (χ2=4.4193，P=0.0355). The age (OR=1.06，95%CI：1.027～1.103，P=0.0006), hypertension (OR=1.15，95% CI：1.065～1.236，P=0.0003), and diabetes (OR=0.85，95% CI：0.726～0.994，P=0.0421) were correlated with LA. Neither age (r=0.1553，χ2=4.9701，P=0.5477) nor the course of hypertension (r=-0.0758，χ2=1.9076，P=0.7527） were correlated with the severity of LA. Conclusion The age and hypertension was independent risk factors for LA, but the severity of LA was not correlated with age or course of hypertension.

Key words: leukoaraiosis (LA), related factors, age, hypertension, diabetes