《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (07): 679-680.

• 临床研究 • 上一篇    下一篇

脑功能区胶质瘤手术唤醒麻醉中持续或间断输注舒芬太尼的影响

程灏;王德祥;韩如泉   

  1. 首都医科大学附属北京天坛医院麻醉疼痛科，北京市 100050
  • 收稿日期:2009-05-19 出版日期:2009-07-01 发布日期:2009-07-01

Target Controlled or Intermittent Infusion of Sufentanil during Awake Craniotomy

CHENG Hao,WANG De-xiang,HAN Ru-quan   

  1. Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2009-05-19 Published:2009-07-01 Online:2009-07-01

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摘要： 目的 比较神经外科唤醒麻醉中持续或间断输注舒芬太尼对呼吸和循环的影响。方法 脑功能区胶质瘤择期开颅手术患者40例，分为A组（n=20）和B组（n=20），分别采取间断或持续输注舒芬太尼的方法行唤醒麻醉。记录术中用药量及呼吸和循环相关指标。结果 B组舒芬太尼用药量明显大于A组（P<0.01），呼吸频率低于A组（P<0.05），呼气末CO2浓度高于A组（P<0.05）。结论 在脑功能区占位手术唤醒麻醉中，间断给予舒芬太尼在不增加静脉麻醉药用量并保证镇痛效果的前提下降低镇痛药的用药量，减轻呼吸抑制的发生。

关键词: 脑功能区, 胶质瘤, 唤醒麻醉, 舒芬太尼, 呼吸抑制

Abstract: Objective To compare the efficacy and safety of the target controlled administration of sufentanil and intermittent sufentanil during awake craniotomy. Methods 40 patients were randomized into target controlled infusion of sufentanil group (n=20) and intermittent sufentanil group (n=20) and compared. Results The hemodynamic parameters were similar in the two groups. However, target controlled infusion of sufentanil was associated with significantly lower respiratory rate （P<0.05）, higher end tidal CO2 （P<0.05）, and higher dosage of sufentanil （P<0.01）, compared with those of intermittent sufentanil. Conclusion Intermittent sufentanil infusion is associated with less respiratory depression than target controlled administration of sufentanil in awake craniotomy.

Key words: cerebral function zone, glioma, awake anesthesia, sufentanil, respiratory depression