《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (11): 1021-1023.

• 基础研究 • 上一篇    下一篇

脑型利尿钠肽前体氨基端肽与心脏舒缩功能的相关性研究

蔡毅1a;范利1b;何昆仑1a;闫丽辉1a;冷文修1a   

  1. 1.解放军总医院，a.南楼综合外二科;b.南楼临床部，北京市 100853
  • 收稿日期:2009-08-28 修回日期:2009-09-27 出版日期:2009-11-01 发布日期:2009-11-01
  • 通讯作者: 范利

Correlation between N-terminal Pro-brain Natriuretic Peptide and Cardiac Diastolic and Systolic Function

CAI Yi,FAN Li,HE Kun-lun,et al   

  1. The Second Department of South Building Comprehensive Surgery, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2009-08-28 Revised:2009-09-27 Published:2009-11-01 Online:2009-11-01

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摘要： 目的 研究脑型利尿钠肽前体氨基端肽(NT-proBNP)与心脏舒缩功能的相关性。方法 雄性新西兰兔60只随机分为2组：手术组在右侧肾动脉上1 cm处行腹主动脉缩窄术；假手术组作为对照组。术后观察心衰的临床表现，监测超声心动图和血清NT-proBNP变化，并进行相关分析。结果 NT-proBNP与收缩期峰速（Sm）（r=－0.635,P=0.000）、舒张早期峰速（Em）（r=－0.693,P=0.000）、E/Em（r=0.688,P=0.000）和二尖瓣舒张早期血流峰速度（E）/左室内舒张早期血流播散速度（Vp）（r=0.707, P=0.000）均存在良好的相关性，而与射血分数（EF）也有相关性（r=－0.395,P=0.001）。结论 通过检测血清NT-proBNP浓度可以有效地预测左室的松弛和充盈功能以及长轴收缩功能的变化。

关键词: 脑型利尿钠肽前体氨基端肽, 心脏功能, 超声心动

Abstract: Objective To study the correlation between N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac diastolic and systolic function. Methods 60 New Zealand male rabbits were randomly assigned to two groups. The abdominal aorta 1 cm just above right renal artery were constricted in operated group. The clinical manifestation of heart failure was observed, and cardiac structure and function were investigated with echocardiography. Concentration of serum NT-proBNP was determined regularly. Results The concentration of NT-proBNP was correlated with Sm（r=－0.635,P=0.000）, Em（r=－0.693,P=0.000）, E/Em（r=0.688,P=0.000）, E/Vp（r=0.707, P=0.000）, and EF（r=－0.395,P=0.001）. Conclusion Concentration of serum NT-proBNP could prognose the diastolic and long axis systolic function of left ventricle.

Key words: N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac function, echocardiography