《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (12): 1138-1140.

• 基础研究 • 上一篇    下一篇

适用于猴鼠的实验动物脊髓损伤装置的研制

张翔1;宋伟2;杨朝阳1,3;廖凯1;牛海军1;李晓光1,3   

  1. 1.北京航空航天大学生物与医学工程学院，北京市 100191;2.中国康复研究中心康复工程研究所，北京市 100068;3.首都医科大学神经生物学系，北京市 100069
  • 收稿日期:2009-09-28 出版日期:2009-12-25 发布日期:2009-12-25
  • 通讯作者: 李晓光

A New Design of Impactor for Rat and Monkey's Spine Cord Injury Models

ZHANG Xiang,SONG Wei,YANG Zhao-yang,et al   

  1. School of Biological Science and Medical Engineering of BUAA, Beijing 100191, China
  • Received:2009-09-28 Published:2009-12-25 Online:2009-12-25

PDF (PC)

被引次数

4

摘要： 脊髓损伤是致残率很高的创伤，严重影响患者的生活质量。建立标准的动物模型对研究其发生机制、病理变化有重要意义。本文设计一种定量损伤实验动物的脊髓打击器，通过该装置特殊设计，实现对动物脊髓的定点、定量打击，可以制作出不同程度损伤的动物模型，并且操作简单、不受人为干扰、精度高、重复性好。本文最后讨论该装置的应用前景与改进方向。

关键词: 脊髓损伤, 动物模型, 损伤装置

Abstract: Spinal cord injury is very high morbidity trauma, seriously affecting the survival and health of patients. To establish a standard animal model has a great significance for studying SCI pathogenesis and pathological changes. A spinal cord injury device for experimental animal was presented in this paper. It can implement fixed-point and fixed-quantity impact by new design. It also can create many animal models of different levels injury. More importantly, it has many advantages such as simple to operate, free from human disturbance, high accuracy and reproducibility. Finally, some existing constraints and challenges about the animal spinal cord injury models made by the device were discussed.

Key words: spinal cord injury, animal models, impact device