《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (10): 904-906.

• 论文 • 上一篇    下一篇

地黄苏合香合剂对轻微肝性脑病模型大鼠治疗的实验研究

刘赫1，梁妍1，刘雁勇1，杨楠1，纪超1，左萍萍1，龚韬2，廖磊2，侯晓明2，蔡哲3   

  1. 1.中国医学科学院基础医学研究所；北京协和医学院基础学院药理室，北京市100005；2.北京市中药研究所中药化学室，北京市100035；3.卫生部中日友好医院临床医学研究所免疫学研究室，北京市 100029。
  • 收稿日期:2010-06-08 修回日期:2010-09-13 出版日期:2010-10-25 发布日期:2010-10-25
  • 通讯作者: 左萍萍

Therapeutical Effects of Rehmannia and Storesin on Minimal Hepatic Encephalopathy in Rat Mode

lLIU He, LIANG Yan，LIU Yan-yong, et al   

  1. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing 100005, China
  • Received:2010-06-08 Revised:2010-09-13 Published:2010-10-25 Online:2010-10-25

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被引次数

13

摘要： 目的观察中药地黄、苏合香(地苏合剂)对四氯化碳(CCl4)致轻微肝性脑病(MHE)大鼠模型的治疗作用。方法采用灌胃给予CCl4致化学性肝损伤大鼠模型，通过开场实验和Morris水迷宫实验，观察地苏合剂低、中、高3个剂量组对模型鼠自发运动、空间记忆能力的影响，并检测肝脾及血液生化学指标；阳性药采用乳果糖。结果造模12周后发现MHE模型鼠的自发运动明显减少，Morris水迷宫空间记忆能力明显下降；服用地苏合剂12周后高剂量治疗组模型鼠的自发运动和空间学习记忆明显改善(P<0.01，P<0.05)；同时血中丙氨酸氨基转移酶(ALT)和血氨(Amm)浓度明显低于未治疗组(P<0.05，P<0.01)。结论地苏合剂对轻微肝性脑病模型大鼠有明显的治疗作用。

关键词: 地黄, 苏合香, 轻微肝性脑病, 行为学, 丙氨酸氨基转氨酶, 血氨

Abstract: ObjectiveTo assess the effects of rehmannia and storesin on minimal hepatic encephalopathy(MHE) in rat model.MethodsMHE rat model was induced by carbon tetrachloride (CCl4) intragastric administration. The effects of rehmannia and storesin on spontaneous movement and learning and memory function of model animals were evaluated with open field test and Morris water maze in 3 dose groups. Lactulose was used in the positive group.ResultsThe spontaneous movement and the spatial learning and memory ability of the model rats both improved significantly in the high dose group. Meanwhile, the serum level of alanine transarninase(ALT) and ammonia(Amm) also decreased in the high dose group.ConclusionRehmannia and storesin has therapeutical effect on MHE rat model.

Key words: rehmannia, storesin, minimal hepatic encephalopathy, behavior, alanine transarninase, ammonia