《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (10): 918-921.

• 论文 • 上一篇    下一篇

视觉完形负波在评价托吡酯及丙戊酸钠对癫痫患者早期认知功能损害中的应用

孙伟1，毛薇1，王玉平1，王薇薇2，吴逊2   

  1. 1.首都医科大学宣武医院，北京市 100053；2.北京大学第一医院，北京市 100034。
  • 收稿日期:2010-09-09 修回日期:1900-01-01 出版日期:2010-10-25 发布日期:2010-10-25
  • 通讯作者: 王玉平，王薇薇

Cognitive Impairment in Epileptics with Topiramate or Valproate Treatment by Visual Completion Negativity

SUN Wei, MAO Wei, WANG Yu-ping, et al   

  1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2010-09-09 Revised:1900-01-01 Published:2010-10-25 Online:2010-10-25

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摘要： 目的评价不完整面孔视觉加工中事件相关电位的特征及其在评价托吡酯及丙戊酸钠对癫痫患者认知损害的应用价值。方法30例未经治疗的癫痫患者分为两组：托吡酯治疗组及丙戊酸钠治疗组(各15例)；另选择15名健康志愿者作为对照组。刺激物采用成对陌生且表情中性的灰阶面孔照片，刺激序列分2个状态：①完整状态(状态1)：S1和S2为相同或不同面孔相片；①不完整状态(状态2)：S1和S2为相同或不同面孔相片，且S2部分遮盖。S1和S2依次呈现，受试者任务：决定S2与S1是否为相同面孔相片，而忽略S2是否部分被遮盖，同步记录事件相关电位。结果3组受试者在面孔不完整状态下，均诱发出P100(P1)和N170(N1)。与完整面孔相比，不完整面孔在枕颞区诱发出明显增大的面孔负波N1，并且存在着右侧优势。在不完整面孔状态下，托吡酯组用药后N1波幅低于用药前(P<0.05)；丙戊酸钠组在用药前、后N1峰波幅没有差别(P>0.05)。结论不完整面孔在枕颞区诱发出明显增大的面孔负波N170(N1)；托吡酯对癫痫患者N1的损害较丙戊酸钠明显。

关键词: 癫痫, 托吡酯, 丙戊酸钠, 事件相关电位N170, 认知

Abstract: ObjectiveTo evaluate the cognitive impairment in epilepsy patients with topiramate (TPM) or valproate (VPA) treatment by using visual completion negativity of faces.Methods30 epileptic patients were divided into two groups receiving TPM or VPA, respectively. 15 healthy volunteers were included as controls. Unfamiliar grey-scale photographs of faces (front view) were used as stimuli. Two types of visual stimuli were presented randomly: pictures of complete faces, pictures of incomplete faces (the occluded part was the left-top quadrant).ResultsN170 were elicited in all participants in each condition. The peak latency of N1 elicited by incomplete faces was delayed compared with complete faces in two groups. Under incomplete faces, a decreased and delayed N170 was observed only in TPM group (P<0.05). N170 amplitude and latency did not change in VPA group (P>0.05).ConclusionChanges of N170 is more obvious in patients with TPM than VPA. Cognitive impairment was not present in epilepsy patients with VPA treatment.

Key words: epilepsy, valproate, topiramate, N170, cognitive