《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (10): 931-933.

• 论文 • 上一篇    下一篇

阿托伐他汀预处理对兔脊髓缺血再灌注损伤的影响

牒军1，王坤正1，李幸洲2   

  1. 1.西安交通大学医学院第二附属医院骨一科，陕西西安市 710004；2.西安市第四医院骨科，陕西西安市 710001。
  • 收稿日期:2010-09-29 修回日期:2010-10-18 出版日期:2010-10-25 发布日期:2010-10-25

Effects of Atorvastatin Pretreatment on Spinal Cord Ischemia-reperfusion Injury of Rabbits

DIE Jun, WANG Kun-zheng, LI Xing-zhou   

  1. Department of the First Orthopaedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China
  • Received:2010-09-29 Revised:2010-10-18 Published:2010-10-25 Online:2010-10-25

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被引次数

4

摘要： 目的研究不同剂量阿托伐他汀预处理后，家兔脊髓缺血再灌注损伤模型行为学及生化学改变，评价阿托伐他汀预处理对脊髓缺血再灌注损伤的影响。方法用腹主动脉夹闭法制备脊髓缺血再灌注模型，缺血45 min，分别于动物再灌注2 h、6 h、12 h、24 h行动物行为学评分；再灌注24 h后，截取脊髓组织。检测脊髓组织匀浆中的丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性及髓过氧化物酶(MPO)活性。结果实验动物缺血再灌注12 h、24 h后行为学评分明显下降，中高剂量阿托伐他汀能明显增强SOD活性、降低MDA含量及MPO活性。结论阿托伐他汀预处理对脊髓缺血再灌注损伤有一定的神经保护作用，其疗效与剂量有关。

关键词: 阿托伐他汀, 脊髓, 缺血再灌注

Abstract: ObjectiveTo explore the atorvastatin impact of pretreatment on spinal cord ischemia-reperfusion injured model of rabbits.MethodsThe animal model was induced by occlusion abdominal aorta. Spinal cord was performed for 45 min ischemia and neuronal function was evaluated at 2 h, 6 h, 12 h, and 24 h after reperfusion. The contents of malonydialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) were assayed 24 h after reperfusion.ResultsThe neuronal function decreased significantly 12 h and 24 h after reperfusion. The activity of SOD significantly enhanced, MDA contents and the activity of MPO decreased at medium-dose and high-dose atorvastatin.ConclusionAtorvastatin has protective effect on the spinal cord ischemia-reperfusion injury of rabbits.

Key words: atorvastatin, spinal cord, ischemia-reperfusion