《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (10): 942-944.

• 论文 • 上一篇    下一篇

可卡因成瘾机制的研究进展

王瑨1，侯柏村1，刘宏亮2，姚忠祥3   

  1. 1.第三军医大学学员旅四队，重庆市 400038；2.第三军医大学西南医院康复理疗科，重庆市 400038；3.第三军医大学生理学教研室，重庆市 400038。
  • 收稿日期:2010-07-19 修回日期:1900-01-01 出版日期:2010-10-25 发布日期:2010-10-25
  • 通讯作者: 刘宏亮，姚忠祥

Advance in Mechanism on Cocaine Addiction (review)

WANG Jin, HOU Bai-cun, LIU Hong-liang, et al   

  1. Squadron 4 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China
  • Received:2010-07-19 Revised:1900-01-01 Published:2010-10-25 Online:2010-10-25

PDF (PC)

被引次数

9

摘要： 可卡因是当今世界主要的成瘾性药物之一，科学家们一直在试图揭示可卡因成瘾的机制，从而找到治疗可卡因成瘾的方法。经典的机制是可卡因通过与多巴胺转运体结合，抑制多巴胺的重摄取，导致大脑内的多巴胺能神经元持续兴奋，使服用者产生快感并成瘾；而最新发现可卡因影响某些与“奖赏”回路中基因表达有关的系统，并且这种影响最终导致该区域神经元树突可塑性发生改变，造成该环路中基因表达的持久性变化，而这些变化可能是可卡因成瘾的某些行为效应的基础。目前的治疗方向主要是利用特异的抗体，疫苗或者酶来减少可卡因与大脑内神经元的接触。本文将对可卡因的成瘾机制及治疗研究的进展与前景进行综述。

关键词: 可卡因, 多巴胺转运体, 甲基化

Abstract: Cocaine is one of the main addiction drugs in the world. Scientists are always trying to discover why the addiction happens and find the methods to cure the cocaine addiction. The classics mechanism is that the cocaine binds with the dopamine transporter (DAT), then the retake of dopamine was blocked, and this resulted in the sustained excitement of the dopaminergic neuron. Now, it is found that the cocaine influence some systems relate to the gene expression of the "reward" circuit. This influence finally leads to the change of neuron dendritic plastisity in that area. All the changes are sustaining and these may be the foundation of some behavior effects about the cocaine addiction. At present, the main therapy orientation is decrease the contact between the cocaine and the neuron by idiosyncratic antibody, vaccine or enzyme. Here, related mechanism and therapies were mainly reviewed.

Key words: cocaine, dopamine transporter (DAT), methylation