《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (11): 1029-1030.

• 论文 • 上一篇    下一篇

莫诺苷对家兔血小板聚集的影响

王晓锋1,2,3，陈乃宏2，王文3   

  1. 1.天津中医药大学，天津市 300193；2.中国医学科学院药物所，北京市 100050；3.首都医科大学宣武医院，北京市 100053
  • 收稿日期:2010-07-30 修回日期:2010-09-02 出版日期:2010-11-25 发布日期:2010-11-25
  • 通讯作者: 陈乃宏、王文

Effects of Morroniside on Platelet Aggregation in Rabbit

WANG Xiao-feng, CHEN Nai-hong, WANG Wen   

  1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2010-07-30 Revised:2010-09-02 Published:2010-11-25 Online:2010-11-25

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摘要： 目的研究莫诺苷对二磷酸腺苷(ADP)、花生四烯酸(AA)、血小板活化因子(PAF)诱导兔血小板聚集的影响。方法采用Born法，检测不同条件下ADP、AA、PAF诱导的兔血小板聚集率。结果与空白对照组相比，莫诺苷能显著抑制由ADP、AA、PAF诱导的兔血小板聚集（P<0.001），尤对ADP的抑制作用选择性强。结论莫诺苷具有明显抑制兔血小板聚集的作用。

关键词: 莫诺苷, 血小板聚集, 兔

Abstract: ObjectiveTo study the effects of Morroniside on platelet aggregation in rabbits induced by Adenosine diphosphate (ADP), Arachidonic acid (AA), Platelet activating factor (PAF). MethodsThe platelet aggregation was determined by Born's method. ResultsCompared with the controls, Morroniside inhibited platelet aggregation induced by ADP, AA, PAF （P<0.001）and especially selective on ADP. ConclusionMorroniside inhibited platelet aggregation in rabbits, especially induced by ADP.

Key words: Morroniside, platelet aggregation, rabbits