《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (11): 1044-1046.

• 论文 • 上一篇    下一篇

卵圆孔未闭患者并发缺血性脑血管病的影响因素

郭鸣1a,2，马欣1a，王彩荣1b，华扬1c   

  1. 1.首都医科大学宣武医院，a.神经内科;b.心脏超声科;c.血管超声科,北京市 100053
  • 收稿日期:2010-10-18 修回日期:1900-01-01 出版日期:2010-11-25 发布日期:2010-11-25
  • 通讯作者: 马欣

Related Factors of Ischemic Cerebrovascular Disease in Patients with Patent Foramen Ovale

GUO Ming, MA Xin, WANG Cai-rong, et al   

  1. Department of Neurology, Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2010-10-18 Revised:1900-01-01 Published:2010-11-25 Online:2010-11-25

PDF (PC)

摘要： 目的观察卵圆孔未闭（PFO）患者并发缺血性脑血管病的影响因素。方法连续选取低于55岁的脑梗死或者短暂性脑缺血发作住院患者，将其中通过经食管超声心动图检查证实存在PFO且行阿司匹林治疗的42例患者按照复发情况分为两组，未复发组36例，复发组6例，比较两组的危险因素和PFO大小及并发房间隔动脉瘤（ASA）情况。结果平均随访时间（523.00±126.20） d。未复发组纤维蛋白原水平为(3.33±1.11) g/L，复发组为(4.40±1.49) g/L（P=0.032）。两组患者PFO直径（P=0.618）及并发ASA情况无显著性差异(P=0.554)。Logistic回归分析显示，纤维蛋白原水平与脑血管病复发无关（OR=2.656,95%CI:0.977～7.219），既往缺血性脑血管病史是复发的危险因素（OR=46.913,95%CI:2.371～928.254）。结论既往存在缺血性脑血管病史的PFO患者再发缺血性脑血管病的危险性较大。还不能确定纤维蛋白原水平在PFO患者发生脑缺血过程中的作用。

关键词: 卵圆孔未闭, 脑梗死, 短暂性脑缺血发作, 复发, 纤维蛋白原

Abstract: ObjectiveTo investigate the related factors of ischemic cerebrovascular diseases in patients with patent foramen ovale (PFO). Methods42 patients with PFO，aged ≤55 years old, with cerebral infarction or transient ischemic attack and treated with aspirin were involved. All patients were examined with transesophageal echocardiography. 6 cases relapsed and 36 cases did not. The size of PFO, serum fibrinogen level, and combination of atrial septal aneurysm (ASA) were compared. ResultsThey were followed up for (512.51±127.38) d. The serum fibrinogen level was (3.33±1.11) g/L in no relapse group, and was (4.40±1.49) g/L in relapse group （P=0.032）. There was not significant difference in the size of PFO (P=0.618) and combination ASA (P=0.554) between these groups. Logistic regression showed that patients with ischemic cerebrovascular diseases history involved in relapse (OR=46.913,95%CI:2.371～928.254), but the serum fibrinogen level did not （OR=2.656,95%CI:0.977～7.219）. ConclusionThe PFO patients with history of ischemic cerebrovascular diseases incline to relapse. It is not sure the influence of the serum fibrinogen level on it.

Key words: patent foramen ovale, cerebral infarction, transient ischemic attack, relapse, fibrinogen