《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (12): 1108-1110.

• 论文 • 上一篇    下一篇

加倍剂量酒石酸托特罗定治疗脊髓损伤致逼尿肌过度活动的效果观察

丛惠伶，廖利民   

  1. 1.首都医科大学康复医学院，北京市 100068；2.中国康复研究中心北京博爱医院泌尿外科，北京市 100068。
  • 收稿日期:2010-11-15 修回日期:1900-01-01 出版日期:2010-12-25 发布日期:2010-12-25
  • 通讯作者: 廖利民

Effect of Double Dosage Tolterodine on Detrusor Overactivity after Spinal Cord Injury

CONG Hui-ling, LIAO Li-min   

  1. Department of Urology, Beijing Charity Hospital, China Rehabilitation Research Center, Capital Medical University School of Rebabilitation Medicine, Beijing 100068, China
  • Received:2010-11-15 Revised:1900-01-01 Published:2010-12-25 Online:2010-12-25

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摘要： 目的观察加倍剂量酒石酸托特罗定治疗脊髓损伤所致膀胱过度活动的临床效果。方法采用自身对临床试验对30例患有膀胱过度活动症的脊髓损伤患者且使用酒石酸托特罗定2 mg/次，每日两次治疗，4周后效果不佳者，加倍剂量(4 mg, 每日两次)进行治疗，以排尿日记和生活质量评分观察其治疗的效果。主观感受评价采用国际尿失禁咨询委员会尿失禁问卷表简表(ICI-Q-SF)。结果4周后30例患者有28例完成试验，2例患者因口干不能耐受退出。28例患者使用加倍剂量酒石酸托特罗定治疗后每次导尿量由(196.3±44.7) ml增加到(393.5±54.3) ml。漏尿次数由每天(4.96±2.15)次减少到(3.92±2.14)次。ICI-Q-SF评价显示，治疗后改善25例，无效3例。结论脊髓损伤导致的膀胱过度症在可耐受口干的条件下酒石酸托特罗定加倍剂量可有效增加膀胱容量，减少漏尿次数。

关键词: 酒石酸托特罗定, 脊髓损伤, 膀胱过度活动

Abstract: ObjectiveTo evaluate the effect of double dosage tolterodine (4 mg/d) on patients with detrusor overactivity after spinal cord injury (SCI).Methods30 patients with detrusor overactivity after SCI who poorly responsed to tolterodine (2 mg/d) were treated with double dosage tolterodine. Urine leakage and quality of life by ICI-Q-SF was used to assess the treatment effect.Results28 of 30 patients completed this study after 4 weeks. 2 patients quited for dry mouth. After treatment with double dosage tolterodine, bladder capacity increased significantly from (196.3±44.7) ml to (393.5±54.3) ml, urine leakage decreased from (4.96±2.15) to (3.92±2.14) times per day. 25 of the 28 patients showed improvement in quality of life by ICI-Q-SF. ConclusionTreatment with double dosage tolterodine showed improvements in bladder capacity and urine leakage in patients with detrusor overactivity after SCI if the patients could tolerate the dry mouth and other side effects.

Key words: tolterodine, spinal cord injury, detrusor overactivity