《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (12): 1110-1113.

• 论文 • 上一篇    下一篇

小肠黏膜下层在膀胱扩大应用中的研究进展

王祎明，廖利民   

  1. 1.首都医科大学康复医学院，北京市 100068；2.中国康复研究中心北京博爱医院泌尿科，北京市 100068。
  • 收稿日期:2010-11-15 修回日期:1900-01-01 出版日期:2010-12-25 发布日期:2010-12-25
  • 通讯作者: 廖利民

Advance in Small-intestinal Submucosa for Bladder Augmentation (review)

WANG Yi-ming, LIAO Li-min   

  1. Department of Urology, Beijing Charity Hospital, China Rehabilitation Research Center, Capital Medical University School of Rebabilitation Medicine, Beijing 100068, China
  • Received:2010-11-15 Revised:1900-01-01 Published:2010-12-25 Online:2010-12-25

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摘要： 目前，利用肠来源组织重建尿路的方法的需求重新激发人们对包括膀胱再生等研究的兴趣。小肠黏膜下层(small intestinal submucosa, SIS)是一种无细胞、非免疫源性、可生物降解、异体胶原基质的材料。它来源于猪的SIS，被证明在多个器官系统有再生能力，包括主动脉、腔静脉、韧带、肌腱、腹壁以及皮肤。本文综述关于膀胱再生工程研究的发展历史，膀胱再生技术，SIS用于膀胱扩大的动物实验方法、初步研究成果以及今后研究方向等内容。

关键词: 小肠黏膜下层, 膀胱再生, 膀胱扩大术, 综述

Abstract: The need to find an alternative to the use of bowel for urinary reconstruction has renewed research interests involving bladder regeneration. Small intestinal submucosa (SIS) is an acellular, nonimmunogenic, biodegradable, xenogeneic, collagen-based material that is derived from the submucosa layer of porcine small intestine. SIS has demonstrated regenerative capacities in multiple organ systems, including the aorta, vena cava, ligaments, tendons, abdominal wall, and skin. This article reviewed the history of the development of the bladder regeneration and the studies involving the use of SIS for bladder augmentation.

Key words: small intestinal submucosa, bladder regeneration, cystoplasty, review