《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (3): 271-272.

• 论文 • 上一篇    下一篇

γ-氨基丁酸B2受体基因rs3750344多态与汉族人骨密度及骨矿量的关系

李蕾1，陈慧敏2，蒋晓燕3，陈艳4，许俐4   

  1. 1.复旦大学生命科学学院遗传研究所，上海市 200433；2.浙江省中医院预防保健科，浙江杭州市 310009；3.同济大学医学院药理教研室，上海市 200092；4.济南市妇幼保健院妇科内分泌, 山东济南市 250001。
  • 收稿日期:2009-12-04 修回日期:1900-01-01 出版日期:2010-03-25 发布日期:2010-03-25
  • 通讯作者: 蒋晓燕

Association between γ-Aminobutyric Acid B2 Receptor Gene Polymorphism rs3750344 and Bone Mass Content or Bone Mass Density in Chinese Hans Population

LI Lei, CHEN Hui-min, JIANG Xiao-yan, et al.   

  1. Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
  • Received:2009-12-04 Revised:1900-01-01 Published:2010-03-25 Online:2010-03-25

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摘要： 目的探讨γ-氨基丁酸B2受体(GABABR2)基因第二外显子rs3750344单核苷酸多态性（SNP）与骨密度的关联。方法425名健康志愿者采用双能X线骨密度仪测量全身各个部位的骨密度和骨矿量，用Taqman基因分型平台进行rs3750344基因分型。结果SNP rs3750344位点TT、TC及CC基因型携带者个体的上肢、下肢、躯干、肋骨、骨盆和全身总骨密度、骨矿量均依次显著增加。结论GABABR2基因rs3750344多态的C等位基因增加汉族人骨密度骨及骨矿量的水平。

关键词: γ-氨基丁酸(GABA), 受体, 基因多态, 骨密度（BMD）, 骨矿量（BMC）

Abstract: ObjectiveTo investigate the association of γ-aminobutyric acid B2 receptor (GABABR2) gene polymorphism rs3750344 and bone mass (bone mass content, BMC, and bone mass density, BMD) in population of Chinese Hans lives in Jinan. Methods425 volunteers were recruited. BMC and BMD of all subjects were measured with dual energy X-ray absorptiometry (DXA). Genotyping of polymorphism rs3750344 was conducted using Taqman assays. ResultsBMD and BMC increased with the copy of the C allele of rs3750344 in whole body. ConclusionThe C allele of GABABR2 rs3750344 increases the levers of BMD and BMC in Chinese Han population.

Key words: γ-Aminobutyric acid (GABA), receptor, polymorphism, bone mass content (BMC), bone mass density (BMD)