《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (5): 408-410.

• 论文 • 上一篇    下一篇

心血管疾病患者血清超敏C-反应蛋白与摄氧效率斜率的相关性研究

李寿霖1,2a，孟申1,2a，刘杰1,2a，林伟1,2a，张焱1,2a，张京1,2b，林亚静1,2a，陈思远1,2a，王国栋1,2a，雒生杰1,2a，杨祖福1,2a   

  1. 1.首都医科大学康复医学院，北京市 100068；2.中国康复研究中心北京博爱医院，a.心血管内科；b.检验科，北京市 100068。
  • 收稿日期:2010-03-19 修回日期:1900-01-01 出版日期:2010-05-25 发布日期:2010-05-25

Correlation between High-sensitivity C Reactive Protein and Oxygen Uptake Efficiency Slope in Patients with Cardiovascular Disease

LI Shou-lin, MENG Shen, LIU Jie, et al.   

  1. Department of Cardiovasology, Capital Medical University School of Rehabilitation Medicine, Beijing Charity Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2010-03-19 Revised:1900-01-01 Published:2010-05-25 Online:2010-05-25

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4

摘要： 目的探讨心血管疾病患者炎症因子超敏C-反应蛋白（hs-CRP）与摄氧效率斜率（OUES）的相关性。方法选择经皮冠状动脉介入治疗后患者17例，稳定型心绞痛21例，原发性高血压24例。采用症状限制性标准Bruce分级平板运动方案，同时测定摄氧量（VO2）、每分通气量（VE）。采用对数曲线拟合的方法，建立回归方程：VO2=a×lgVE+b，计算a为OUES值。应用全自动免疫散射比浊法检测血清hs-CRP。超声心动图测定左心室射血分数（LVEF）。结果血清lg(hs-CRP)与OUES75（r=-0.506,P＜0.001）、OUES100（r=-0.567,P＜0.001）、LVEF（r=-0.286,P＜0.01）呈负相关。多元逐步回归分析显示，lg(hs-CRP)（β=-0.374，P=0.006）、身高（β=-1.854，P=0.036）、体重（β=-5.033，P=0.034）是OUES75降低的危险因素；lg(hs-CRP)（β=-0.396，P=0.003）、身高（β=-2.157，P=0.013）、体重（β=-5.912，P=0.011）是OUES100降低的危险因素。结论血清hs-CRP可能是反映心肺储备功能及左室收缩功能的有效标记物。

关键词: 冠状动脉疾病, 高血压, 稳定型心绞痛, 超敏C-反应蛋白, 摄氧效率斜率, 心肺运动试验

Abstract: ObjectiveTo investigate the relationship between high-sensitivity C reactive protein （hs-CRP） and oxygen uptake efficiency slope (OUES) in patents with cardiovascular disease. MethodsExercise tests, following a symptom-limited standard Bruce protocol with simultaneous respiratory gas-exchange measurements, were performed on a treadmill in 17 post-PCI patients, 21 stable angina pectoris and 24 patients with essential hypertension (EH). The oxygen uptake (VO2), minute ventilation (VE) were determined. The OUES was derived from the relation between VO2 (ml/min) and VE (L/min) during incremental exercise and was determined by VO2=a×lgVE+b, where a = OUES. The OUES was calculated from data of the first 75% (OUES75) and 100% (OUES100) of exercise duration. The serum hs-CRP was measured by immunoassays, and the left ventricular ejection fraction (LVEF) was measured with echocardiography. ResultsOUES75 （r=-0.506,P＜0.001）, OUES100 （r=-0.567,P＜0.001） and LVEF （r=-0.286,P＜0.01） were correlated with lg(hs-CRP). In stepwise multivariable linear regression models, lg(hs-CRP) （β=-0.374，P=0.006）, body height （β=-1.854，P=0.036）, body weight （β=-5.033，P=0.034）were independent risk factors of lower OUES75. lg(hs-CRP) （β=-0.396，P=0.003）, body height （β=-2.157，P=0.013）, body weight （β=-5.912，P=0.011） were independent risk factors of lower OUES100. ConclusionThe serum leveles of hs-CRP may be the useful marker that reflecting cardiopulmonary functional reserve and left ventricular function.

Key words: coronary artery disease, essential hypertension, stable angina pectoris, high-sensitivity C reactive protein, oxygen uptake efficiency slope, exercise tests