《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (5): 457-459.

• 论文 • 上一篇    下一篇

急性脑梗死血浆血栓烷B2、氧化型低密度脂蛋白、脂蛋白（a）、同型半胱氨酸相关性分析

王峥1,2，高枫1，郝洪军1，孙伟平1   

  1. 1. 北京大学第一医院神经科, 北京市 100034；2. 南京医科大学第一附属医院老年医学科，江苏南京市 210029。
  • 收稿日期:2010-01-28 修回日期:2010-03-11 出版日期:2010-05-25 发布日期:2010-05-25
  • 通讯作者: 高枫

Correlation among Thromboxane B2, Oxidized Low Density Lipoprotein, Lipoprotein(a), and Homocysteine in Patients with Cerebral Infarction

WANG Zheng, GAO Feng, HAO Hong-jun, et al.   

  1. Departement of Neurology, the First Hospital, Peking University, Beijing 100034, China
  • Received:2010-01-28 Revised:2010-03-11 Published:2010-05-25 Online:2010-05-25

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摘要： 目的探讨脑梗死的相关因素血栓烷B2(TXB2)、氧化型低密度脂蛋白(OxLDL)、脂蛋白(a)［Lp(a)］、同型半胱氨酸（Hcy）在脑梗死中的作用以及彼此之间的相关性。方法急性脑梗死患者205例，正常对照组40例。分别检测发病24 h内的血浆TXB2、6-酮-前列环素1α（6-keto-PGF1α）含量及其比值(TXB2/6-keto-PGF1α，T/6-K)、OxLDL、Lp(a)、Hcy的含量，进行组间比较和相关性分析。结果和结论脑梗死患者血浆TXB2、T/6-K，OxLDL、Lp(a)、Hcy含量均明显高于正常对照组(P<0.01)。OxLDL与Lp(a)呈正相关；TXB2与T/6-K、Hcy呈正相关；T/6-K与OxLDL、Lp（a)呈正相关。

关键词: 脑梗死, 血栓烷B2（TXB2）, 氧化型低密度脂蛋白(OxLDL), 脂蛋白(a)［Lp(a)］, 同型半胱氨酸（Hcy）, 相关性

Abstract: ObjectiveTo study the relevant pathogenic factors, Thromboxane B2 (TXB2), oxidized low density lipoprotein (OxLDL), lipoprotein(a) (Lp(a)), and homocysteine (Hcy), in patients with cerebral infarction and the correlation among them. Methods205 patients and 40 health persons (the control) were measured with the plasma TXB2, 6-keto-prostaglandin F1α (PGF1α) and TXB2/6-keto-PGF1α (T/6-K), OxLDL, Lp(a), Hcy within 24 h. Results and ConclusionThe levels of plasma TXB2, T/6-K，OxLDL, Lp(a), and Hcy significantly increased compared with the controls (P<0.01). OxLDL was correlated with Lp(a); TXB2 was correlated with T/6-K and Hcy; T/6-K was correlated with OxLDL, Lp（a）.

Key words: cerebral infarction, Thromboxane B2 (TXB2), oxidized low density lipoprotein (OxLDL), lipoprotein(a) (Lp(a)), homocysteine (Hcy), correlation