《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (6): 587-588.

• 论文 • 上一篇    下一篇

苯海拉明在药物诱发痫样脑电图试验中的应用

胡萌，刘欣友，符晓慧，黄敏，李臻，张中银   

  1. 中山大学附属东华医院神经内科，广东东莞市 523110。
  • 收稿日期:2010-03-04 修回日期:1900-01-01 出版日期:2010-06-25 发布日期:2010-06-25

Application of Benadrly in Test of Drug-induced Electroencephalography of Epilepsy

HU Meng, LIU Xin-you, FU Xiao-hui, et al.   

  1. Department of Neurology, Donghua Hospital Affiliated to Zhongshan University, Dongguan 523110, Guangdong, China
  • Received:2010-03-04 Revised:1900-01-01 Published:2010-06-25 Online:2010-06-25

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摘要： 目的观察苯海拉明在药物诱发试验中癲痫脑电图(EEG)阳性率检出的效果。方法324例临床诊断的癫痫患者，采用开放随机分组对照研究的方法分为苯海拉明组(162例)和水合氯醛组(162例)，两组分别进行睡眠诱发EEG检查，观察两组痫样放电率以及非快速动眼(NREM)睡眠痫样放电容易出现的时期。结果苯海拉明组有7例脱落。药物诱发试验：苯海拉明组阳性49例，痫样放电率31.61%；水合氯醛组阳性30例，痫样放电率18.52%。苯海拉明组药物诱发试验痫样放电阳性率比水合氯醛组明显高(χ2=7.26, P<0.01)。NREM睡眠Ⅰ～Ⅱ期痫样放电检出率：苯海拉明组为83.7%；水合氯醛组为63.3%。提示NREM睡眠Ⅰ～Ⅱ期是痫样放电容易出现时期，且苯海拉明组癫痫放电阳性率比水合氯醛组高(χ2=4.22, P<0.05)。结论苯海拉明在癫痫药物诱发试验中可作为首选药物之一。

关键词: 苯海拉明, 诱发试验, 癫痫, 脑电图

Abstract:

ObjectiveTo explore the relationship between the test of drug-induced electroencephalography(EEG) and epilepsy.Methods324 patients with epilepsy were randomly divided into 2 groups, the benadrly group(n=162) and chloral hydrate group(n=162) as control. EEG was examined by evoking during sleep to observe epileptiform discharge and which stage of non-rapid eye movements (NREM) epileptiform discharge occurred more frequently.ResultsThe epileptiform discharge was 31.61% in benadrly group, and 18.52% in chloral hydrate group. There was significant difference between the two groups (P<0.01). The detection rate of epileptiform discharge at the stage I～II of NREM was significantly higher in benadrly group (83.7%) than in chloral hydrate group(63.3%)(P<0.05), which suggested that epileptiform discharge frequently occurred at the stage I～II of NREM.ConclusionBenadrly is superior to chloral hydrate in the test of drug-induced EEG of epilepsy.

Key words: benadrly, drug-induced test, eilepsy, electroencephalography