《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (7): 648-649.

• 论文 • 上一篇    下一篇

抗癫痫药对癫痫患者认知功能的影响

孙伟1，毛薇1，王玉平1，王薇薇2，吴逊2   

  1. 1.首都医科大学宣武医院神经内科，北京市 100053;2.北京大学第一医院神经内科，北京市 100034。
  • 收稿日期:2010-05-10 修回日期:1900-01-01 出版日期:2010-07-25 发布日期:2010-07-25
  • 通讯作者: 王玉平、王薇薇

Impact of Antiepileptic Drugs on Cognitive Function of Epilepsy Patients

SUN Wei, MAO Wei, WANG Yu-ping, et al.   

  1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beiing 100053, China
  • Received:2010-05-10 Revised:1900-01-01 Published:2010-07-25 Online:2010-07-25

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摘要： 目的探讨应用中国韦氏成人智力量表（WAIS-CR）评价托吡酯与丙戊酸钠对癫痫患者认知功能的损害。方法30例未经治疗的癫痫患者随机分为两组：托吡酯治疗组及丙戊酸钠治疗组 （各15例）。所有患者在入组前及入组后3个月进行WAIS-CR问卷调查。结果托吡酯治疗组治疗前、后智力测定平均总IQ为（90.40±4.84）、（81.00±6.61）（P<0.05）；丙戊酸钠治疗组治疗前、后智力测定平均总IQ分值为（88.33±4.70）、（87.40±5.34）（P>0.05）。结论托吡酯在用药早期影响癫痫患者的认知功能，使患者的总智商（FIQ）下降。

关键词: 癫痫, 托吡酯, 丙戊酸钠, 认知, 韦氏成人智力量表

Abstract: ObjectiveTo evaluate the cognitive impairment in epilepsy patients with Topiramate (TPM) or Valproate (VPA) treatment by using WAIS-CR. Methods30 untreated epilepsy patients were divided into two groups receiving TPM or VPA, respectively. All the patients were examined with WAIS-CR before and 3 months after treatment. ResultsThe IQ of TPM group decreased 3 months after treatment (P<0.05). ConclusionTPM may impair the cognitive function in epileptics reflected by decreased IQ.

Key words: epilepsy, Topiramate, Valproate, cognition, Wechsler Adult Intelligence Scale