《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (7): 670-671.

• 论文 • 上一篇    下一篇

铝镁匹林对尿11-脱氢血栓素B2影响的长期观察

黄岩，樊朝美，王杨，黄一玲，王莉，边文彦，李一石   

  1. 北京协和医学院中国医学科学院阜外心血管病医院,卫生部心血管药物临床研究重点实验室,临床药理中心，北京市 100037。
  • 收稿日期:2010-06-07 修回日期:1900-01-01 出版日期:2010-07-25 发布日期:2010-07-25
  • 通讯作者: 李一石

Inhibition of Urine 11-dH-TXB2 by Dihydroxyaluminum Aminoacetate-Heavy Magnesium Carbonate-Aspirin: A Long-term Result

HUANG Yan, FAN Chao-mei, WANG Yang, et al.   

  1. The Key Laboratory of Clinical Trial Research of Cardiovascular Drugs, Clinical Pharmacology Center, Fuwai Cardiovascular Hospital， PUMC and CAMS, Beijing 100037, China
  • Received:2010-06-07 Revised:1900-01-01 Published:2010-07-25 Online:2010-07-25

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摘要： 目的观察铝镁匹林抑制患者尿11-脱氢血栓素B2(11-dH-TXB2)的长期效果。方法103例患者给予铝镁匹林2片（含阿司匹林162 mg）口服。于用药前及用药6周、12周、24周后分别测定尿11-dH-TXB2。结果尿11-dH-TXB2治疗前及治疗后6周、12周、24周分别为（1840.41±1452.63） pg/ml、（820.01±610.55） pg/ml、（1011.19±1148.12） pg/ml、（1290.82±1425.51） pg/ml。12周时较6周时略有回升，但无显著性差异（P=0.1016）；24周较12周升高（P=0.0283）。结论铝镁匹林有明显的抗血小板聚集作用，但长期口服后作用可能有减弱的趋势。

关键词: 阿司匹林, 血小板聚集, 尿11-脱氢血栓素B2

Abstract: ObjectiveTo evaluate the inhibition of urine 11-dH-TXB2 by dihydroxyaluminum aminoacetate-heavy magnesium carbonate-aspirin in Chinese cardiovascular patients after long-term therapy. Methods103 cardiovascular patients were treated with oral doses of dihydroxyaluminum aminoacetate-heavy magnesium carbonate-aspirin tablets (162 mg aspirin) daily for 24 weeks. The Urine 11-dH-TXB2 concentration were measured before and 6, 12, 24 weeks after administration. ResultsThe urine 11-dH-TXB2 concentration were （1840.41±1452.63） pg/ml, （820.01±610.55） pg/ml, （1011.19±1148.12） pg/ml, （1290.82±1425.51） pg/ml before and 6, 12, 24 weeks after administration. The urine 11-dh-TXB2 concentration was higher in 24th week than in 12th weeks and 6th week. ConclusionThe dihydroxyaluminum aminoacetate-heavy magnesium carbonate-aspirin can inhibit the platelet aggregation, which decreased after long-term administration.

Key words: aspirin, platelet aggregation, 11-dH-TXB2