《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (8): 707-710.

• 论文 • 上一篇    下一篇

阿片类药物诱导痛觉过敏的分子生物学机制

王强1,2，李树人3，崔伟华3   

  1. 1.首都医科大学康复医学院，北京市 100068；2.北京博爱医院麻醉科，北京市 100068；3.首都医科大学附属北京友谊医院麻醉科，北京市 100050
  • 收稿日期:2010-07-27 修回日期:1900-01-01 出版日期:2010-08-25 发布日期:2010-08-25

Molecular Biological Mechanism of Opioids Induced Hyperalgesia(review)

WANG Qiang, LI Shu-ren, CUI Wei-hua   

  1. Capital Medical University School of Rehabilitation Medicine, Beijing Charity Hospital, China Rehabilitation Center, Beijing 100068, China
  • Received:2010-07-27 Revised:1900-01-01 Published:2010-08-25 Online:2010-08-25

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摘要： 阿片类药物能够激活体内的促伤害机制，导致机体对疼痛的敏感性增高，即阿片诱导的痛觉过敏。目前它的机制并不确定，可能与中枢谷氨酸能系统活性增强、阿片受体功能改变、外周受体的作用、内源性神经肽的作用、抑制性神经递质受体系统功能降低以及信号转导通路中的成分发生变化等方面有关。

关键词: 阿片类药物, 痛觉过敏, 分子生物学, 综述

Abstract: Opioids can activate the pro-nociceptive channel by which the sensitivity to pain has been increased, which is called opioids induced hyperalgesia (OIH). The mechanism of OIH has not been identified, but it is possibly involved in the increased activity of central glutamatergic system, changed function of opioid receptors, roles of peripheral receptors, effects of endogenous neuropeptides, decreased function of inhibitory neurotransmission system, and changed elements in signal transduction pathway, etc.

Key words: opioids, hyperalgesia, molecular biology, review