《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (9): 807-808.

• 论文 • 上一篇    下一篇

早期康复介入对急性脑梗死炎症反应的影响

甘照儒1a，石丽华1a，蔡超群1a，谢智光1b，徐英妹2，刘海朋2，桑栎楠2   

  1. 1.广西中医学院附属瑞康医院,a.神经内科;b.检验科,广西南宁市 530011;2.广西中医学院,广西南宁市 530003。
  • 收稿日期:2010-06-29 修回日期:1900-01-01 出版日期:2010-09-25 发布日期:2010-09-25

Effect of Early Rehabilitation on Inflammatory Response after Acute Cerebral Infarction

GAN Zhao-ru, SHI Li-hua, CAI Chao-qun, et al   

  1. Department of Neurology, Ruikang Hospital of Guangxi Traditional Chinese Medical University, Nanning 530011, Guangxi, China
  • Received:2010-06-29 Revised:1900-01-01 Published:2010-09-25 Online:2010-09-25

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被引次数

27

摘要： 目的观察早期康复治疗对急性脑梗死（ACI）患者的运动功能、血清超敏C-反应蛋白(hs-CRP)、白细胞介素-1（IL-1）和白细胞介素-6（IL-6）含量动态变化的影响。方法160例ACI患者随机分为两组，康复组80例采用早期康复治疗和常规中西药物治疗，对照组80例仅采用常规中西药物治疗。测定两组患者治疗前和治疗后1、2、4、8周后外周血hs-CRP、IL-1和IL-6含量，用改良爱丁堡-斯堪的纳维亚脑卒中评定表（MESSS）进行神经功能评定。结果康复组治疗后4、8周时外周血hs-CRP、IL-1和IL-6水平低于对照组（P＜0.05）；MESSS评分明显低于对照组（P＜0.01），康复组临床总有效率高于对照组（P＜0.05）。结论早期康复干预可降低急性脑梗死患者患者血清hs-CRP、IL-1和IL-6水平，并降低临床神经功能缺损程度，提高临床疗效。

关键词: 急性脑梗死, 早期康复, 超敏C-反应蛋白, 白细胞介素-1, 白细胞介素-6, 神经功能

Abstract: ObjectiveTo observe the effect of early rehabilitation on motor function, high-sensitivity C-reactive protein (hs-CRP), interleukin-1（IL-1） and interleukin-6（IL-6） in patients with acute cerebral infarction (ACI). Methods160 patients with ACI were randomly divided into rehabilitation group (n=80) and control group (n=80), who accepted early rehabilitation and routine medicine or medicine only, respectively. They were assessed with modified Edinburgh-Scandinavian Stroke Scale (MESSS) and their peripheral level of hs-CRP, IL-1 and IL-6 were detected before and 1, 2, 4, and 8 weeks after treatment. Results4 and 8 weeks after treatment, the level of hs-CRP, IL-1 and IL-6 were lower in rehabilitation group than in control group（P＜0.05）, as well as the scores of the MESSS （P＜0.01）. The incidence of improvement is more in rehabilitation group than in control group（P＜0.05）. ConclusionEarly rehabilitation can reduce the expression of hs-CRP, IL-1 and IL-6, and improve the neurological function in patients with ACI.

Key words: acute cerebral infarction, early rehabilitation, high-sensitivity C-reactive protein, interleukin-1, interleukin-6, neurological function