《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (9): 809-810.

• 论文 • 上一篇    下一篇

重组人粒细胞集落刺激因子治疗急性脑梗死74例疗效观察

杜平，张家伟，王海军，王铁岩   

  1. 1.齐齐哈尔医学院康复教研室，黑龙江齐齐哈尔市 161000；2.齐齐哈尔医学院附属第三医院康复医学科，黑龙江齐齐哈尔市 161000。
  • 收稿日期:2010-07-20 修回日期:1900-01-01 出版日期:2010-09-25 发布日期:2010-09-25

Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Acute Cerebral Infarction: 74 Cases Report

DU Ping, ZHANG Jia-wei, WANG Hai-jun, et al   

  1. Department of Rehabilitation Medicine, The Third Affiliated Hospital, Qiqihar Medical University, Qiqihar 161000, Heilongjiang, China
  • Received:2010-07-20 Revised:1900-01-01 Published:2010-09-25 Online:2010-09-25

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被引次数

6

摘要： 目的探讨重组人粒细胞集落刺激因子(rhG-CSF)治疗急性脑梗死的疗效。方法74例急性脑梗死患者分为治疗组和对照组，每组37例。两组均按急性脑梗死常规方法治疗，治疗组在此基础上加用rhG-CSF。两组于治疗前、治疗后3个月时分别进行中国卒中量表(CSS)评定，并观察rhG-CSF治疗期间的不良反应。结果治疗后两组CSS评分均改善(P<0.05)，且治疗组优于对照组(P<0.05)。rhG-CSF治疗期间未出现明显不良反应。结论rhG-CSF治疗急性脑梗死安全有效。

关键词: 脑梗死, 骨髓干细胞, 重组人粒细胞集落刺激因子

Abstract: ObjectiveTo explore the effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on acute cerebral infarction.Methods74 patients with acute cerebral infarction were divided into treatment and control groups. Two groups were treated by conventional methods of acute cerebral infarction; the treatment group was treated with rhG-CSF additionally. The two groups were measured before and 3 months after treatment by China Stroke Scale (CSS), respectively. Meanwhile, the side effect of rhG-CSF was observed during treatment.ResultsCSS score was better in the treatment group than in the control group 3 months after treatment (P＜0.05). No side effect occurred in the treatment group.ConclusionrhG-CSF is safe and effective to treat acute cerebral infarction.

Key words: cerebral infarction, bone marrow stem cells, recombinant humangranulocyte colony-stimulating factor (G-CSF)