《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (9): 811-812.

• 论文 • 上一篇    下一篇

局部注射A型肉毒毒素对于脑卒中后下肢痉挛患者的影响

卢宇，刘景隆，李浩   

  1. 哈尔滨市解放军第211医院康复理疗科，黑龙江哈尔滨市 150080。
  • 收稿日期:2010-07-19 修回日期:2010-09-10 出版日期:2010-09-25 发布日期:2010-09-25

Effects of Intramuscular Botulinum Toxin Type A Injection on Spasticity of Lower Limb after Stroke

LU Yu, LIU Jing-long, LI Hao   

  1. Department of Rehabilitation, Harbin PLA 211 Hospital, Harbin 150080, Heilongjiang, China
  • Received:2010-07-19 Revised:2010-09-10 Published:2010-09-25 Online:2010-09-25

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摘要： 目的评估局部注射A型肉毒毒素(BTX-A)对于脑卒中后下肢痉挛患者的痉挛程度、步行功能以及日常生活活动能力(ADL)的影响。方法13例脑卒中后下肢痉挛的患者行局部注射BTX-A,分别在治疗前，治疗后1周、4周、8周和12周应用综合痉挛量表(CSS)、步长和步行速度、Barthel指数(BI)进行评估。结果治疗后下肢痉挛程度降低，BI升高(均P<0.05)。步长和步行速度虽有提高，但是无显著性差异(P>0.05)。所有改善均出现在治疗后1周，并持续至第12周。结论下肢局部注射BTX-A可以改善脑卒中后下肢痉挛患者的痉挛程度，提高ADL。

关键词: 脑卒中, 痉挛, 下肢, A型肉毒毒素, 步行, 日常生活活动能力

Abstract: ObjectiveTo investigate the effects of intramuscular Botulinum toxin type A (BTX-A) injection on spasticity of lower limb, walking and activities of daily living (ADL) after stroke. Methods13 patients with spasticity on lower limb were injected intramuscularly with BTX-A, and assessed with Composite Spasticity Scale (CSS), step length and gait velocity, and Barthel index (BI) before and 1, 4, 8 and 12 weeks after treatment. ResultsThe scores of CSS and BI significantly improved after treatment (P<0.05). There was some improvement in step length and gait velocity, but not significant (P>0.05). All the improvement appeared 1 week after injection and lasted to the 12th week. ConclusionLocal intramuscular BTX-A injection can reduce the spasticity on lower limb and improve ADL.

Key words: stroke, spasticity, lower limb, Botulinum toxin type A, walking, activities of daily living