《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (9): 841-842.

• 论文 • 上一篇    下一篇

p38 MAPK信号转导通路与椎间盘退变

文天用，李放，叶超群   

  1. 北京军区总医院骨科，北京市 100700。
  • 收稿日期:2010-04-02 修回日期:1900-01-01 出版日期:2010-09-25 发布日期:2010-09-25
  • 通讯作者: 李放

p38 MAPK Signaling Pathway and Disc Degeneration (review)

WEN Tian-yong, LI Fang, YE Chao-qun   

  1. Department of Orthopaedics, Beijing Army General Hospital, Beijing 100700, China
  • Received:2010-04-02 Revised:1900-01-01 Published:2010-09-25 Online:2010-09-25

PDF (PC)

被引次数

13

摘要： p38 MAPK信号通路是丝裂原活化蛋白激酶(MAPK)介导的信号转导通路的重要分支，它在炎症、细胞应激、凋亡、细胞周期和生长等多种生理和病理过程中起重要作用。既往在骨关节炎的研究中发现，p38参与炎性因子的激活、软骨细胞的凋亡等，与骨关节炎的病理过程密切相关。椎间盘退变也存在炎性反应、细胞凋亡等病理变化，这其中p38 MAPK信号转导通路发挥的作用尚不明确。现将既往此类文献加以综述。

关键词: p38, 丝裂原活化蛋白激酶, 椎间盘退变, 综述

Abstract: p38 signaling pathway is an important branch of mitogen-activated protein kinase（MAPK)-mediated signal transduction pathway. It plays pivotal roles in various physiological and pathological events, such as inflammation, cell stress, apoptosis, cell cycle and growth. Previous research in osteoarthritis, p38 participation was found in the inflammatory factors activate, cartilage cell apoptosis etc. Disc degeneration, also associated with inflammatory response, apoptosis and pathological changes which p38 MAPK signaling pathways role is not clear. Some reports about this area are reviewed in this article.

Key words: p38, mitogen-activated protein kinase, disc degeneration, review