《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (9): 856-858.

• 论文 • 上一篇    下一篇

人脑干和幕上胶质瘤N-cadherin和β-catenin mRNA的表达

马俊艳1，武文浩2，田永吉2，历俊华1，张力伟2，万虹1，郝淑煜2，李德志2，阴鲁鑫2   

  1. 1.首都医科大学北京市神经外科研究所,北京市 100050；2.首都医科大学附属北京天坛医院,北京市 100050。
  • 收稿日期:2010-06-03 修回日期:1900-01-01 出版日期:2010-09-25 发布日期:2010-09-25
  • 通讯作者: 万虹

Expression of N-cadherin and β-catenin mRNA in Human Brainstem or Supratentorial Gliomas

MA Jun-yan, WU Wen-hao, TIAN Yong-ji, et al   

  1. Beijing Neurosurgical Institute, Capital Medical Univercity, Beijing 100050, China
  • Received:2010-06-03 Revised:1900-01-01 Published:2010-09-25 Online:2010-09-25

PDF (PC)

被引次数

5

摘要： 目的探讨N-cadherin和相关因子β-catenin mRNA在人脑干和幕上胶质瘤中的表达。方法采用RT-PCR法检测N-cadherin和β-catenin mRNA在18例脑干胶质瘤和18例幕上胶质瘤中的表达。结果N-cadherin mRNA在脑干和幕上胶质瘤中的表达无显著性差异(P＞0.05)，β-catenin mRNA在脑干胶质瘤中的表达高于幕上胶质瘤（t=2.255,P<0.05）；N-cadherin mRNA在脑干胶质瘤中随着肿瘤级别的升高而增高(t=2.711，P<0.05)，在幕上胶质瘤各级别表达无显著性差异。β-catenin mRNA在不同级别脑干和幕上胶质瘤中的表达均无显著性差异(P>0.05)；N-cadherin和β-catenin mRNA在脑干和幕上胶质瘤中的表达均呈正相关（r=0.480，r=0.809,均P<0.05）。结论N-cadherin和β-catenin的过度表达在人脑干胶质瘤的侵袭及恶性进展中起着重要作用。

关键词: 神经胶质瘤, 神经-钙粘素, β-连环蛋白, 脑干, 幕上

Abstract: ObjectiveTo explore the expression of N-cadherin and β-catenin mRNA in human brainstem and supratentorial gliomas. MethodsN-cadherin and β-catenin mRNA expression in 18 cases of brainstem gliomas and 18 cases of supratentorial gliomas tissues were detected with PT-PCR. Resultsβ-catenin mRNA expression was more in human brainstem gliomas than in supratentorial gliomas （t=2.255,P<0.05）, but was not significantly different of N-cadherin mRNA (P＞0.05). The expression of N-cadherin mRNA in human brainstem gliomas of grades Ⅰ～Ⅱ were less than those in human gliomas of grades Ⅲ～Ⅳ (t=2.711，P<0.05), but was not of β-catenin mRNA (P＞0.05). N-cadherin mRNA expression was positively correlated with the β-catenin mRNA expression in either brainstem gliomas or supratentorial gliomas （r=0.480，r=0.809 respectively, P<0.05）. ConclusionThe over expressions of N-cadherin and β-catenin may play an important role in the invasion and malignant progress of human brainstem gliomas.

Key words: glioma, N-cadherin, β-catenin, brainstem, supratentorial