《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (10): 990-992.

• 论文 • 上一篇    下一篇

尼可地尔对慢性充血性心力衰竭患者心脏功能及血糖的影响

李跃艳   

  1. 南华大学附属第一医院心血管内科，湖南衡阳市421001。
  • 收稿日期:2011-08-22 修回日期:2011-09-22 出版日期:2011-10-25 发布日期:2011-10-25

Effects of Nicorandil on Cardiac Function and Blood Glucose in Chronic Heart Failure

LI Yue-yan.   

  1. Department of Cardiology, the First Affiliated Hospital, University of South China, Hengyang 421001, Hunan, China
  • Received:2011-08-22 Revised:2011-09-22 Published:2011-10-25 Online:2011-10-25

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摘要： 目的观察尼可地尔对慢性充血性心力衰竭患者心脏功能及血糖的影响。方法64 例慢性心衰患者随机分为对照组(n=32)和治疗组(n=32)，对照组使用常规抗心衰及基础疾病治疗药物，治疗组在使用上述药物的基础上口服ATP 敏感钾离子(KATP)通道开放剂尼可地尔(nicorandil, NCR)，5 mg/次，每日3 次，疗程12 周。观察治疗前后6 分钟步行距离实验(6MWT)、血浆氨基末端脑钠肽前体(NT-proBNP)、空腹血浆血糖(FPG)、餐后2 小时血糖(P2hPG)、糖化血红蛋白A1c (GHbA1c)的变化。结果治疗后，两组患者6 分钟步行距离及血浆NT-proBNP 水平均改善(P<0.01)，治疗组优于对照组(P<0.05)；FPG、P2hPG、GHbA1c 在组间比较均无显著性差异(P>0.05)。结论尼可地尔能提高慢性充血性心力衰竭患者运动耐量，降低血浆NT-proBNP 水平，且对血糖水平无明显影响。

关键词: 尼可地尔, 心力衰竭, 6 分钟步行实验, 脑钠肽, 运动耐量, 血糖

Abstract: Objective To explore the effects of nicorandil on cardiac function and blood glucose in patients with chronic heart failure(CHF). Methods 64 patients with CHF were randomly divided into control group and treatment group. Both 2 groups received conventionaltherapy for heart failure. And the treatment group was treated with nicorandil additionally (5 mg once, 3 times a day for 12 weeks). 6-minutewalk text (6MWT), plasma N-terminal-pro brain natriuretic peptide (NT-proBNP), fasting plasma glucose (FPG), postprandial 2 hours plasmaglucose (P2hPG) and glycated hemoglobin A1c (GHbA1c) were measured before and after treatment. Results After the treatment, the6-minute walking distance and the plasma NT-proBNP levels of both groups were improved significantly (P<0.01), especially in treatmentgroup (P<0.05); the level of FPG, P2hPG and GHbA1c were not significantly different between 2 groups. Conclusion Nicorandil can effectivelyimprove the exercise tolerance of the patients with CHF, reduce the Plasma NT-proBNP level, but it has no effect on the level of bloodglucose.

Key words: nicorandil, chronic heart failure, 6-Minute Walk Test, brain natriuretic peptide, exercise tolerance, blood glucose