《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (11): 1035-1038.

• 论文 • 上一篇    下一篇

丘脑在舒芬太尼中枢镇痛中的作用

刘晓媛1a，李欢冬2，张磊1b，罗芳1a，王保国3   

  1. 1.首都医科大学附属北京天坛医院，a.麻醉疼痛科；b.神经放射科，北京市100050；2.中国科学院自动化研究所模式识别国家重点实验室，中法信息、自动化与应用数学联合实验室，北京市100050；3.首都医科大学附属北京三博脑科医院麻醉疼痛科，北京市100093。
  • 收稿日期:2011-09-02 修回日期:1900-01-01 出版日期:2011-11-25 发布日期:2011-11-25
  • 通讯作者: 王保国

Role of Thalamus in Central Analgesia of Sufentanil: a Functional Magnetic Resonance Imaging Study

LIU Xiao-yuan, LI Huan-dong, ZHANG Lei, et al.   

  1. Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2011-09-02 Revised:1900-01-01 Published:2011-11-25 Online:2011-11-25

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摘要： 目的探讨舒芬太尼的中枢镇痛机制。方法选择健康受试者17 例(男8 例，女9 例)，依次在基础阶段和靶控输注舒芬太尼(0.2 ng/ml)后行功能磁共振(fMRI)扫描。选取丘脑为感兴趣脑区，应用SPM软件对所有实验数据进行处理。结果靶控输注舒芬太尼后，与丘脑功能连接减弱的脑区包括双侧额叶直回、左侧额叶眶后回；与丘脑功能连接增强的脑区包括双侧小脑、右侧扣带回及左侧颞中回(P<0.001, cluster>13 mm3)。结论丘脑是舒芬太尼中枢镇痛机制中起到重要作用的脑区。额叶直回、左侧额叶眶后回、右侧扣带回、小脑及左侧颞中回与丘脑间功能连接的变化可能是舒芬太尼中枢镇痛机制中的重要组成部分。

关键词: 舒芬太尼, 功能磁共振成像, 功能连接, 丘脑

Abstract: Objective To explore the analgesic mechanisms of sufentanil. Methods 17 (8 male, 9 female) healthy right-handed volunteersreceived functional magnetic resonance imaging (fMRI) scan before and after sufentanil 0.2 ng/ml administration respectively. Thalamuswas as the region of interest (ROI). All the processing works were carried out using the Statistical Parametric Mapping. Results Comparedwith the basic state, significantly weaker functional connectivity was mainly found in the region of bilateral rectal gyrus and the left inferiaorbital gyrus of the frontal lobe, while significantly greater functional connectivity was found in bilateral cerebellum, the right cingulategyrus and the left middle temporal gyrus (P<0.001, cluster>13 mm3). Conclusion Thalamus plays a key role in the central analgesia ofsufentanil, which associated with the functional connectivity of bilateral rectal gyrus and the left inferia orbital gyrus of the frontal lobe, bilateralcerebellum, the right cingulate gyrus and the left middle temporal gyrus.

Key words: sufentanil, functional magnetic resonance imaging, functional connectivity, thalamus