《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (11): 1039-1043.

• 论文 • 上一篇    下一篇

丘脑在经皮穴位电刺激镇痛效果中的作用

张磊1a，罗芳1b，李欢冬2，王保国3，刘晓媛1b   

  1. 1.首都医科大学附属北京天坛医院，a.麻醉疼痛科；b.神经放射科，北京市100050；2.中国科学院自动化研究所模式识别国家重点实验室，中法信息、自动化与应用数学联合实验室，北京市100050；3.首都医科大学附属北京三博脑科医院麻醉疼痛科，北京市100093。
  • 收稿日期:2011-09-02 修回日期:1900-01-01 出版日期:2011-11-25 发布日期:2011-11-25
  • 通讯作者: 刘晓媛

Role of Thalamus in Analgesia of Transcutaneous Acupoint Electrical Stimulation: a Functional Magnetic Resonance Imaging Study

ZHANG Lei, LUO Fang, LI Huan-dong, et al.   

  1. Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2011-09-02 Revised:1900-01-01 Published:2011-11-25 Online:2011-11-25

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摘要： 目的探讨丘脑在经皮穴位电刺激镇痛中的作用。方法选择健康受试者14 例(男7 例，女7 例)，依次在基础阶段和经皮穴位电刺激30 min 后行功能磁共振(fMRI)扫描。选取丘脑为感兴趣脑区，应用SPM软件对所有试验数据进行处理。结果经皮穴位电刺激后，与丘脑功能连接减弱的脑区包括双侧楔前叶、双侧顶上小叶、左侧颞下回、右侧颞中回、右侧额中回；与丘脑功能连接增强的脑区包括双侧小脑、双侧岛叶、基底神经节、双侧额下回、左侧额叶眶回、左侧颞上回(P<0.005, cluster>10mm3)。结论丘脑在经皮穴位电刺激镇痛的中枢镇痛机制中起到了重要作用。小脑、楔前叶、岛叶、基底神经节、顶上小叶、额叶眶回、额中回、额下回、颞叶等脑区与丘脑间功能连接的改变是丘脑镇痛机制的重要组成部分。

关键词: 经皮穴位电刺激, 丘脑, 功能磁共振, 功能连接

Abstract: Objective To explore the analgesic mechanisms of sufentanil. Methods 17 (8 male, 9 female) healthy right-handed volunteersreceived functional magnetic resonance imaging (fMRI) scan before and after sufentanil 0.2 ng/ml administration respectively. Thalamuswas as the region of interest (ROI). All the processing works were carried out using the Statistical Parametric Mapping. Results Comparedwith the basic state, significantly weaker functional connectivity was mainly found in the region of bilateral rectal gyrus and the left inferiaorbital gyrus of the frontal lobe, while significantly greater functional connectivity was found in bilateral cerebellum, the right cingulategyrus and the left middle temporal gyrus (P<0.001, cluster>13 mm3). Conclusion Thalamus plays a key role in the central analgesia ofsufentanil, which associated with the functional connectivity of bilateral rectal gyrus and the left inferia orbital gyrus of the frontal lobe, bilateralcerebellum, the right cingulate gyrus and the left middle temporal gyrus.

Key words: sufentanil, functional magnetic resonance imaging, functional connectivity, thalamus