《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (11): 1046-1048.

• 论文 • 上一篇    下一篇

神经阻滞联合普瑞巴林治疗带状疱疹后神经痛的研究

申颖，罗芳，王云珍   

  1. 首都医科大学附属北京天坛医院麻醉疼痛科，北京市100050。
  • 收稿日期:2011-09-02 修回日期:1900-01-01 出版日期:2011-11-25 发布日期:2011-11-25
  • 通讯作者: 王云珍

Effect of Nerve Block Combined with Oral Pregabalin on Postherpetic Neuralgia

SHEN Ying, LUO Fang, WANG Yun-zhen.   

  1. Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2011-09-02 Revised:1900-01-01 Published:2011-11-25 Online:2011-11-25

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被引次数

16

摘要： 目的比较单纯口服普瑞巴林和联合神经阻滞两种方法治疗带状疱疹后神经痛(PHN)的效果。方法60 例病程超过6个月的PHN患者分成两组，每组各30 例。A组口服普瑞巴林；B组在口服药物的基础上行神经阻滞(三叉神经、肋间神经、椎旁阻滞或腰丛阻滞)。比较两组患者治疗前、治疗后3 d、1 周、2 周、3 周、4 周、5 周、6 周、7 周、8 周疼痛视觉模拟评分(VAS)和睡眠评分(采用汉密尔顿抑郁量表的第4、5、6 项)。比较两组患者疼痛缓解>50%和>30%的人数，以及副作用的发生率。结果两组患者治疗后1～8 周VAS 和睡眠评分均低于治疗前(P<0.05)，B 组患者在治疗后3 d VAS 及睡眠评分明显低于A组(P<0.01)；B 组患者疼痛缓解>50%的人数和疼痛缓解>30%的人数高于A组(P<0.05)。两组患者副作用无显著性差异。结论神经阻滞联合口服普瑞巴林治疗带状疱疹后神经痛起效快、止痛作用强，无严重副作用发生。

关键词: 带状疱疹后神经痛, 神经阻滞, 普瑞巴林

Abstract: Objective To evaluate the efficacy of pregabalin combined with nerve block on postherpetic neuralgia (PHN). Methods 60patients were assigned into group A (n=30), who received pregabalin orally, and group B (n=30), who received nerve block (trigeminalnerve, intercostal nerve, lumbar nerve block) in addition. They were assessed with visual analogue scale (VAS) of pain, sleep score fromHamilton Rating Scale for Depression before and 3 d, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks, and 8 weeks aftertreatment. The incidence of pain decreased >50% and >30% were compared. Results The scores of VAS and sleep significantly reduced inboth groups 1~8 weeks after treatment (P<0.01), and decreased significantly 3 d after treatment in group B than in group A (P<0.05). The incidenceof pain decreased >50% and >30% were more in group B than in group A (P<0.05). Conclusion Nerve block combined with oralpregabalin is more effective on PHN.

Key words: postherpetic neuralgia, nerve block, pregabalin