《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (4): 334-336.

• 论文 • 上一篇    下一篇

电刺激大鼠上矢状窦旁硬脑膜后血浆降钙素基因相关肽和P物质的变化

董钊，姜磊，于生元   

  1. 解放军总医院神经内科，北京市 100853。
  • 收稿日期:2011-02-22 修回日期:1900-01-01 出版日期:2011-04-25 发布日期:2011-04-25
  • 通讯作者: 于生元

Changes of Plasma Concentration of Calcitonin Gene-related Peptide and Substance P after Electrical Stimulation on Dura Mater Adjacent to Sinus Sagittalis Superior in Rats

DONG Zhao, JIANG Lei, YU Sheng-yuan.   

  1. Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2011-02-22 Revised:1900-01-01 Published:2011-04-25 Online:2011-04-25

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被引次数

8

摘要： 目的观察电刺激上矢状窦旁硬脑膜对大鼠血浆降钙素基因相关肽(CGRP)和P物质浓度的影响。方法13只大鼠随机分为对照组(n=6)和电刺激组(n=7)。对照组行假刺激，电刺激组以20 Hz、4 mA和250 μs的方波电流刺激上矢状窦旁硬脑膜，使用放射免疫法比较血浆CGRP和P物质的浓度。结果对照组与电刺激组的血浆CGRP浓度相比有显著性差异(50.60±7.16 pg/ml vs 42.20±4.82 pg/ml，P＝0.029)，而血浆P物质浓度相比无显著性差异(308.59±43.07 pg/ml vs 264.60±60.28 pg/ml，P＝0.165)。结论电刺激上矢状窦旁硬脑膜能够降低大鼠血浆CGRP浓度，而P物质浓度无明显变化。

关键词: 电刺激, 上矢状窦, 降钙素基因相关肽, P物质, 大鼠

Abstract: ObjectiveTo analyze the changes of plasma concentration of calcitonin gene-related peptide (CGRP) and substance P (SP) after electrical stimulation on dura mater adjacent to sinus sagittalis superior (SSS) in rats.Methods13 rats were randomly divided into control group(n=6) and stimulation group(n=7) in which the dura matter adjacent to SSS was stimulated electrically with square wave of 20 Hz, 4 mA and 250 μs. The plasma concentrations of CGRP and SP in both groups were compared by means of radioimmunity method.ResultsThere was significant difference in the plasma concentration of CGRP between control and stimulation groups (50.60±7.16 pg/ml vs 42.20±4.82 pg/ml, P＝0.029). However, there was no significant difference in the plasma concentration of SP between two groups (308.59±43.07 pg/ml vs 264.60±60.28 pg/ml, P＝0.165).ConclusionPlasma concentration of CGRP decreased after electrical stimulation on dura mater in rats but the concentrations of SP unchanged.

Key words: electrical stimulation, superior sagittal sinus, calcitonin gene related peptide, substance P, rats