《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (5): 433-436.

• 论文 • 上一篇    下一篇

人脑胶质瘤中转化生长因子β2、Smad3 蛋白表达及临床意义1

苏伟1，刘福生1，朱贵东1，姜中利2，金贵善1，柴奇1，曹泽1   

  1. 1.首都医科大学北京市神经外科研究所脑肿瘤研究中心，北京市100050；2.首都医科大学附属北京天坛医院神经外科，北京市 100050。
  • 收稿日期:2011-01-20 修回日期:2011-03-22 出版日期:2011-05-25 发布日期:2011-05-25
  • 通讯作者: 刘福生

Expressions of Transforming Growth Factor β2 and Smad3 in Human Gliomas with Different Pathologic Grade Proliferation and Its Clinical Significance

SU Wei, LIU Fu-sheng, ZHU Gui-dong, et al.   

  1. Beijing Neurosugical Institute, Capital Medical University, Beijing 100050, China
  • Received:2011-01-20 Revised:2011-03-22 Published:2011-05-25 Online:2011-05-25

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摘要： 目的探讨人脑胶质瘤组织中转化生长因子β2(TGF-β2)、Smad3 蛋白表达水平与患者预后的关系。方法应用免疫组化SP 法检测80 例人脑胶质瘤组织TGF-β2、Smad3 蛋白表达水平，并分析其与患者无进展生存期及总生存期的关系。结果TGF-β2蛋白和Smad3 蛋白在不同级别胶质瘤之间表达具有显著性差异(P<0.05)，其表达与病理级别呈正相关(r=0.545，r=0.570，P<0.01)。将所有患者分为TGF-β2 或Smad3 高表达组和低表达组，其无进展生存期和总生存期均有显著性差异(P<0.05)。结论TGF-β2、Smad3 蛋白表达与胶质瘤发生及恶性程度相关；检测两者表达情况可为脑胶质瘤的临床诊治及预后判断提供依据。

关键词: 脑胶质瘤, 转化生长因子β2, Smad3, 免疫组织化学

Abstract: Objective To investigate the expressions of Transforming Growth Factorβ2 (TGF-β2) and Smad3 in human gliomas associated with pathologic grading. Methods The expressions of TGFβ2 and Smad3 protein were detected with SP immunhistochemistry in 80 human glioma specimens. The Kapan-Meier survival curves of progression-free survival time and overall survival time in different expression levels was compared with log-rank. Results The expression of TGFβ2 and Smad3 correlated with the pathological grading (r=0.545, r=0.570, P<0.01). Both progression-free survival time and overall survival time were significantly different between low expression group and high expression group (P<0.05). Conclusion Both TGF-β2 and Smad3 correlate well with the occurrence and differentiation of human gliomas,which help for the diagnosis, treatment and prognosis judgment．

Key words: glioma, transforming growth factor β2, Smad3, immunhistochemistry