《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (5): 446-448.

• 论文 • 上一篇    下一篇

进行性核上性麻痹头部磁共振的神经影像学特点

朴英善，冯涛   

  1. 首都医科大学附属北京天坛医院神经内科，北京市 100050。
  • 收稿日期:2011-04-29 修回日期:1900-01-01 出版日期:2011-05-25 发布日期:2011-05-25
  • 通讯作者: 冯涛

Features of MRI in Progressive Supranuclear Palsy

PIAO Ying-shan, FENG Tao.   

  1. Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Beijing 100050, China
  • Received:2011-04-29 Revised:1900-01-01 Published:2011-05-25 Online:2011-05-25

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摘要： 目的探讨进行性核上性麻痹(PSP)患者头部磁共振检查的神经影像学特点，并与帕金森病(PD)进行比较。方法对17 例PSP 患者和30 例PD患者的常规MRI 检查进行回顾性形态学测量分析。结果17 例PSP 患者均可见矢状位T1加权像中脑上缘平坦或凹陷，PD患者仅有4 例(13%)(P<0.01)；正中矢状位T1加权像上计算中脑断面面积以及中脑与桥脑断面面积比值，PSP 组均低于PD组(P<0.01)；PSP 组与PD组的中脑前后径大小虽然存在差异，但是有明确的重叠现象；PSP 组轴位T2加权像上导水管腹侧出现弥散性高信号，虽然具有较高的特异性，但是具有较低的敏感性。结论MRI 检查中脑萎缩对PSP 具有较高的诊断价值，并能与PD相鉴别。

关键词: 进行性核上性麻痹, 帕金森病, 磁共振成像

Abstract: Objective To investigate the features of magnetic resonance imaging (MRI) in the brain of patients with progressive supranuclear palsy (PSP). Methods 17 patients with PSP and 30 patients with Pakinson disease (PD) were retrospectively studied with MRI. Results The atrophy of the midbrain tegmentum and hummingbird sign were demonstrated in all of the PSP patients studied, but were only flatness observed in 13% of PD patients. The area of the midbrain and the ratio of midbrain versus pons areas in the patients with PSP were significantly smaller than in those with PD. The average of midbrain transverse diameter in PSP was smaller than those in PD, but an overlap was observed. Tegmental T2 hyperintensity had lower sensitivity. Conclusion MRI may be useful to distinguish PSP from PD.

Key words: progressive supranuclear palsy, Parkinson disease, magnetic resonance imaging