《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (5): 454-456.

• 论文 • 上一篇    下一篇

老年高血压患者不同心室构型与氮末端B型脑钠肽前体的相关性

高鹏，朱启伟，杜瑞雪，骆雷鸣   

  1. 解放军总医院南楼心血管二科，北京市 100853。
  • 收稿日期:2011-01-06 修回日期:2011-04-14 出版日期:2011-05-25 发布日期:2011-05-25

Relationship between N-terminal-pro-B-type Natriuretic Peptide and Left Ventricular Mass Index in Elderly Hypertension Patients

GAO Peng, ZHU Qi-wei, DU Rui-xue, et al.   

  1. the 2nd Department of Cardiology, Southern Building Clinic Division, Chinese PLA General Hospital, Beijing 100853，China
  • Received:2011-01-06 Revised:2011-04-14 Published:2011-05-25 Online:2011-05-25

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摘要： 目的分析老年高血压患者不同心脏构型之间的氮末端B 型脑钠肽前体(NT-proBNP)水平差异。方法检查老年高血压患者326 例，正常人265 名NT-proBNP 水平，通过超声测量，按Ganau 分类法，将高血压组左心室质量指数升高的患者分为向心性肥厚型、离心性肥厚型两种构型。结果高血压病组NT-proBNP 水平高于对照组。按心脏重构分组后，向心性肥厚组NT-proBNP 水平升高最多，离心性肥厚组次之，而正常构型组和向心性重构组与对照组没有显著性差异。结论老年高血压患者在未出现心功能失代偿时NT-proBNP 已出现明显升高，且不同构型之间NT-proBNP 水平不同，提示NT-proBNP 可能参与左心室的重构甚至是心功能的恶化。

关键词: 高血压, 老年, 左心室质量指数, 氮末端B型脑钠肽前体

Abstract: Objective To investigate the N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration in the difference myocardial wall motion after essential hypertension. Methods 326 patients with essential hypertension and normal heart function and 265 control subjects were measured with their NT-proBNP. According to Canau's categories, the ventricle geometries of patients with high left ventricular mass index were divided into 2 groups. Results NT-proBNP was significantly higher in patients with hypertension than in controls. After grouped by different myocardial wall motion, the patients with concentric hypertrophy were highest among all the groups; the groups with eccentric hypertrophy was secondly highest; concentric remodeling and normal geometric pattern were not significantly higher than the controls. Conclusion NT-proBNP is different in patients with different myocardial wall motion before heart failure, which may play an important role in myocardial remodeling.

Key words: hypertension, elderly, left ventricular mass index, N-terminal-pro-B-type natriuretic peptide