《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (9): 868-871.

• 论文 • 上一篇    下一篇

一氧化碳中毒迟发性脑病高压氧治疗剂量与疗效

张红霞，刘亚玲，于秋红，薛连璧   

  1. 首都医科大学附属北京天坛医院高压氧科，北京市 100050。
  • 收稿日期:2011-08-09 修回日期:1900-01-01 出版日期:2011-09-25 发布日期:2011-09-25
  • 通讯作者: 薛连璧

Efficacy of Different Doses of Hyperbaric Oxygen Therapy on Delayed Encephalopathy after Carbon Monoxide Poisoning

ZHANG Hong-xia, LIU Ya-ling, YU Qiu-hong, et al.   

  1. Department of Hyperbaric Oxygenation, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
  • Received:2011-08-09 Revised:1900-01-01 Published:2011-09-25 Online:2011-09-25

PDF (PC)

被引次数

29

摘要： 目的探讨高压氧治疗(HBOT)一氧化碳中毒迟发性脑病(DEACMP)的不同剂量与疗效的关系。方法DEACMP 患者68 例分成HBOT 30 次组和HBOT 60 次组，分别于治疗前，治疗后35 d、70 d 进行简易智能精神状态检查量表(MMSE)评分，同时进行脑部MRI+Flair 影像学检查。结果治疗后70 d 时，HBOT 60 次组患者MMSE 评分基本恢复正常，显著高于HBOT 30 次组。脑核磁T2和Flair 序列影像显示大脑半卵圆区和脑室周围区呈弥漫性高信号改变，HBOT 后有所改善。结论HBOT 对DEACMP 具有明显疗效，在患者发病早期开始连续60 次治疗效果最为显著。

关键词: 高压氧治疗, 一氧化碳中毒迟发性脑病, 简易智能精神状态检查量表, 核磁共振成像

Abstract: Objective To evaluate the efficacy of two doses of hyperbaric oxygen therapy (HBOT) on delayed encephalopathy after carbonmonoxide poisoning (DEACMP). Methods 68 patients with DEACMP were divided into two groups, the 30 sessions of HBOT group(30-HBOT group) and the 60 sessions of HBOT group (60-HBOT group), who were given HBOT 30 and 60 times respectively. All patientswere assessed with Mini-Mental State Examination (MMSE) and fluid attenuated inversion recovery (Flair) magnetic resonance imaging ofbrain immediately before, 35 d and 70 d after HBOT. Results The MMSE score was significantly higher in 60-HBOT group than in30-HBOT group 70 d after HBOT (P<0.01). All of patients showed diffuse and confluent hyper-intensity over the bilateral periventricularwhite matter and centrum semiovale on conventional T2WI and Flair, which improved. Conclusion HBOT is effective on DEACMP, especiallywith 60 times.

Key words: hyperbaric oxygen therapy, delayed encephalopathy after carbon monoxide poisoning, Mini-Mental State Examination, magnetic resonance imaging