《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (11): 1029-1032.

• 论文 • 上一篇    下一篇

TNFRSF11B基因多态性与肌肉量的关系

王静1，李响1，解端阳1，陈艳2，蒋晓燕1   

  1. 1.同济大学医学院，心脏病基础研究教育部重点实验室，上海市200092；2.济南市妇幼保健院妇科内分泌，山东济南市250001。
  • 收稿日期:2012-05-17 修回日期:2012-06-13 出版日期:2012-11-25 发布日期:2012-11-25
  • 通讯作者: 李响

Association of TNFRSF11B Polymorphism with Lean Muscle Mass in Population of Chinese Han

WANG Jing, LI Xiang, XIE Duan-yang, et al.   

  1. Tongji University School of Medicine, Key Laboratory for Basic Research in Cardiology, Ministry of Education, Shanghai 200092, China
  • Received:2012-05-17 Revised:2012-06-13 Published:2012-11-25 Online:2012-11-25

PDF (PC)

摘要： 目的研究TNFRSF11B 基因多态性对人肌肉量的影响。方法对419 名汉族健康志愿者测量全身、躯干、上肢、下肢的肌肉量，采用标签单核苷酸多态性(tSNP)策略选择8 个tSNP，进行基因分型。结果TNFRSF11B基因rs2875845 位点AA、AG和GG以及rs1485288 位点CC、CT 和TT 基因型携带者个体左右侧上肢、下肢、躯干肌肉量和全身肌肉量依次增加(P<0.05)。结论TNFRSF11B基因rs2875845 位点的G等位基因及rs1485288 位点的T 等位基因增加汉族人肌肉量的水平。

关键词: TNFRSF11B基因, 单核苷酸多态性, 肌肉量

Abstract: Objective To investigate the association of the TNFRSF11B gene polymorphism and the lean muscle mass in population of Chinese Han living in Jinan. Methods Lean muscle mass of 419 volunteers were measured with dual energy X-ray absorptiometry. 8 tagging single nucleotide polymorphism (tSNP) of TNFRSF11B gene were genotyped. Results Lean muscle mass of whole body increased with the copy of the G allele of TNFRSF11B-rs2875845 and the T allele of TNFRSF11B-rs1485288 (P<0.05). Conclusion The G allele of rs2875845 and the T allele of rs1485288 in TNFRSF11B gene increase the level of the lean muscle mass in Chinese Han population.

Key words: TNFRSF11B gene, single nucleotide polymorphism, lean muscle mass