《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (11): 1040-1043.

• 论文 • 上一篇    下一篇

帕金森病的炎症及抗炎药物的研究进展

张美蓉1,2，孙芳玲1，艾厚喜1，张丽1，蒋莹1，魏守蓉2，王文1   

  1. 1.首都医科大学宣武医院药物研究室，教育部神经变性病学重点实验室，北京市老年病医疗研究中心，北京市100053；2.华中科技大学同济医学院附属梨园医院神经内科，湖北武汉市430077。
  • 收稿日期:2011-11-01 修回日期:2012-08-22 出版日期:2012-11-25 发布日期:2012-11-25
  • 通讯作者: 王文、魏守蓉

Inflammatory and Anti-Inflammatory for Parkinson's Disease (review)

ZHANG Mei-rong, SUN Fang-ling, AI Hou-xi, et al   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053, China
  • Received:2011-11-01 Revised:2012-08-22 Published:2012-11-25 Online:2012-11-25

PDF (PC)

被引次数

43

摘要： 帕金森病是人类最常见的神经退行性运动障碍性疾病之一，其特征是中脑黑质致密部多巴胺能神经元变性丢失，纹状体内多巴胺水平降低，进而引起震颤、肌肉僵直、运动迟缓和姿势步态失调的症状。帕金森病的病理机制复杂，病因目前仍不清楚。但近年来，炎症反应在帕金森病中的作用引起人们的广泛关注，小胶质细胞的激活以及炎性因子的高表达参与帕金森病的发生、发展过程。应用抗炎药物延缓或阻止帕金森病的发生、发展已成为该领域新的研究热点。本文就帕金森病中的炎症机制以及抗炎药物的进展进行综述。

关键词: 帕金森病, 小胶质细胞, 炎症, 抗炎药物, 综述

Abstract: Parkinson's disease (PD) is one of the most prevalent neurodegenerative movement disorder in human being, characterized by progressive degeneration and lost of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc),causing low level of DA in the nigrostriatal pathway, eventually leading to motor dysfunctions including tremor, rigidity, bradykinesia,and postural instability.The pathology of PD is complex and the etiology remains poorly understood. In recent years,inflammation has been suggested to be involved in the occurrence and development of PD, by activation of microglia and overexpression of the inflammatory factors. And anti-inflammatory drugs has been developed to delay or prevent the progressive course of PD, becoming a new hotspot in treatment of PD. In this review, the latest progresses on the inflammatory mechanisms and anti-inflammatory treatments of PD was introduced.

Key words: Parkinson's disease, microglia, inflammation, anti-inflammatory drug, review