《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (12): 1119-1122.

• 论文 • 上一篇    下一篇

快速老化小鼠SAMP8 在阿尔茨海默病研究中的应用

李延峥，李林，张兰   

  1. 首都医科大学宣武医院药物研究室，北京市老年病医疗研究中心，神经变性病教育部重点实验室，北京市100053。
  • 收稿日期:2012-08-02 修回日期:1900-01-01 出版日期:2012-12-25 发布日期:2012-12-25
  • 通讯作者: 张兰

Senescence Accelerated Mouse Prone 8 for Study of Alzheimer's Disease (review)

LI Yan-zheng, LI Lin, ZHANG Lan.   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053, China
  • Received:2012-08-02 Revised:1900-01-01 Published:2012-12-25 Online:2012-12-25

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摘要： 阿尔茨海默病以进行性认知功能障碍、记忆能力下降为主要特征。脑内β-淀粉样蛋白(Aβ)异常沉积、神经原纤维缠结、胆碱能神经元功能减退、突触和树突棘缺失等为阿尔茨海默病特征性病理改变。快速老化小鼠SAMP8 在早期即出现学习记忆功能障碍、Aβ异常沉积、tau 蛋白磷酸化、神经递质改变、突触结构和功能障碍、生理节律紊乱，以及基因表达等多方面的特征性改变，与人类阿尔茨海默病病理改变较为一致，可以作为较理想的动物模型，用于阿尔茨海默病防治药物的研究。

关键词: 阿尔茨海默病, 快速老化小鼠, 动物模型, 综述

Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. The pathological eatures of Alzheimer's disease are abnormal deposition of amyloid beta-peptides (Aβ), neurofibrillary tangles, cholinergic deficits, and loss of synaptic processes and dendritic spines. Senescence accelerated mouse prone 8 exhibits age-related deficits of learning and memory from an early age, tau protein phosphorylation, neurotransmitter changes, synaptic structure and function disorders, circadian rhythm disorders,as well as gene expression and many other characteristic changes, which are consistent with Alzheimer's disease pathological changes，and can be used as an ideal animal model for Alzheimer's disease prevention drugs development.

Key words: Alzheimer's disease, senescence accelerated mouse prone 8, animal model, review