《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (12): 1168-1174.

• 论文 • 上一篇    下一篇

综合康复训练对精神分裂症患者疗效的Meta分析

周玉1a，杨拯1b，邱有波1a，袁梦郎1a，张晓1b   

  1. 1.成都医学院，a.临床医学系；b.实验技术教研室，四川成都市610081。
  • 收稿日期:2012-06-26 修回日期:2012-07-19 出版日期:2012-12-25 发布日期:2012-12-25
  • 通讯作者: 杨拯，张晓

Effect of Comprehensive Rehabilitation Training on Patients with Schizophrenia: A Meta-analysis

ZHOU Yu, YANG Zheng, QIU You-bo, et al.   

  1. Clinical Medicine College, Chengdu Medical College, Chengdu 610081, Sichuan, China
  • Received:2012-06-26 Revised:2012-07-19 Published:2012-12-25 Online:2012-12-25

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摘要： 目的采用Meta 分析评价综合康复训练对精神分裂症患者的康复疗效。方法计算机检索PubMed(2001~2011)、FMJS外文全文数据库(EMCC,1995~2011)、中国期刊全文数据库(CNKI,1989~2011)、维普中文科技期刊全文数据库(VIP, 1989~2011)、中国生物医学文献数据库(CBM,1989~2011)，全面收集有关于综合康复训练治疗精神分裂症的随机对照试验或临床对照试验文献。按照Jadad 量表评价纳入研究文献质量，提取有效数据，采用RevMan 5.0 软件进行Meta 分析。结果共检索到国内外文献596篇，经排查后，纳入研究质量较低的随机或临床对照试验文献共16 篇。Meta 分析结果显示：与常规护理/管理组比较，综合康复训练组阳性症状和阴性症状量表(PANSS)评分[加权均数差(WMD)=-9.21, 95%CI(-10.83, -7.59), Z=11.6, P<0.00001]、日常生活活动能力量表(ADL)评分[WMD=-5.84, 95%CI(-8.74, -2.94), Z=3.94, P<0.0001]、护士用住院患者观察量表(NOSIE)总消极因素评分[WMD=-13.60, 95%CI(-22.41, -4.80), Z=3.03, P=0.002]、NOSIE 总评分[WMD=27.50, 95%CI(16.18, 38.81), Z=4.76, P<0.00001]疗效较优。社会功能缺陷筛选量表(SDSS)评分[WMD=-2.50, 95%CI(-5.33, 0.33), Z=1.73, P=0.08]和NOSIE 总积极因素评分[WMD=15.00, 95%CI(-2.06, 32.06), Z=1.72, P=0.08]，两组间无显著性差异。结论在常规治疗的基础上，综合康复训练能减轻精神分裂症患者的精神症状，提高日常生活能力，降低消极症状，提高患者的生活质量。

关键词: 综合康复训练, 精神分裂症, 疗效, Meta分析

Abstract: Objective To evaluate the effects of comprehensive rehabilitation training on the patients with schizophrenia by Meta-analysis.Methods Articles were searched form PubMed (2001 to 2011), EMCC(1995 to 2011), CNKI(1989 to 2011), VIP(1989 to 2011), and CBM(1989 to 2011), which were randomized controlled trials (RCTs) or controlled clinical trials (CCTs) about comprehensive rehabilitation training for schizophrenia. Quality of included articles was assessed with Jadad Scale, and the available data were analyzed with RevMan 5.0 software. Results 596 related articles were identified, but only 16 eligible articles were included. All the trials were of low quality. Meta-analysis showed that compared comprehensive rehabilitation training could improve the scores of Positive and Negative Syndrome Scale (PANSS) [Weighted Mean Difference (WMD) =-9.21, 95% CI(-10.83, -7.59), Z=11.6, P<0.00001], activites of daily living (ADL) [WMD=-5.84, 95% CI(-8.74, -2.94), Z=3.94, P<0.0001], Nurses' Observation Scale for Inpatient Evaluation (NOSIE) total score [WMD=27.50, 95%CI(16.18,38.81), Z=4.76, P<0.00001] and total score of negative factors [WMD=-13.60, 95%CI(-22.41, -4.80),Z=3.03, P=0.002], compared with those in routine care/management group. There was no significant difference between both groups in Social Disability Screening Schedule (SDSS) [WMD=-2.50, 95% CI(-5.33, 0.33), Z=1.73, P=0.08] and NOSIE total positive factor score [WMD=15.00, 95%CI(-2.06, 32.06), Z=1.72, P=0.08]. Conclusion Comprehensive rehabilitation training can reduce the positive and negative symptoms, improving the ability of daily living and quality of life.

Key words: comprehensive rehabilitation training, schizophrenia, effect, meta-analysis