《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (2): 169-171.

• 论文 • 上一篇    下一篇

盐酸帕罗西汀治疗癫痫并发抑郁的临床研究

伍文清，肖玉莲，陈葵   

  1. 首都医科大学附属北京友谊医院神经内科，北京市 100050。
  • 收稿日期:2011-07-22 修回日期:2011-12-30 出版日期:2012-02-25 发布日期:2012-02-25

Effect of Paroxetine on Epilepsy following Depression

WU Wen-qing, XIAO Yu-lian, CHEN Kui.   

  1. Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2011-07-22 Revised:2011-12-30 Published:2012-02-25 Online:2012-02-25

PDF (PC)

被引次数

30

摘要： 目的评价盐酸帕罗西汀治疗癫痫并发抑郁患者的有效性和安全性。方法对诊断明确的165 例成年癫痫患者进行抑郁功能检测，筛选工具采用患者健康问卷抑郁量表(PHQ-9)；对于PHQ-9 检测分数大于15 的患者进行汉密尔顿抑郁量表(HAMD)评估，共31 例癫痫患者HAMD测试得分大于20。此部分患者在原用抗癫痫药物不变的同时给予盐酸帕罗西汀，20 mg/d，连续服用并观察12 周。观察癫痫的发作频率、副作用变化以及抑郁症状变化情况。分别比较治疗前、治疗12 周后的各项指标。结果29 例癫痫患者完成12 周的药物观察，患者抑郁症状明显改善，HAMD评分由治疗前的(26.7±3.9)分降至治疗后的(13.5±2.2)分(P<0.05)；癫痫发作频率没有明显变化，发作无加重；头晕为最常见的副作用，多数出现在治疗开始后1 个月内；PHQ-9 与HAMD一致率为93.9%。结论盐酸帕罗西汀可以明显改善癫痫患者的抑郁症状，并可使部分患者癫痫发作减少，没有明显的不良反应。

关键词: 癫痫, 抑郁, 盐酸帕罗西汀, 患者健康问卷抑郁量表

Abstract: Objective To assess the efficacy and safety of paroxetine for epileptic patients following depression. Methods 156 epileptic patients were recruited. Patient Health Questionnaire 9-item Depression scale (PHQ-9) then the Hamilton Scale for Depression (HAMD)were the assessment tools. 31 patients, whose score of PHQ-9 more than 15 and HAMD more than 20 were selected. The monthly seizure frequency and depression severity were investigated before and 12 weeks after treatment with paroxetine, 20 mg/d. The side effects of paroxetine were also observed. Results 29 patients completed the observation. The total scores of the HAMD decreased 12 weeks after treatment (P<0.05). Dizziness was the most common adverse event during the first month of treatment. No seizure worsening was observed. Monthly seizure frequency did not change significantly. Conclusion Paroxetine is a safe and effective antidepressant for epileptic patients following depression.

Key words: epilepsy, depression, paroxetine, Patient Health Questionnaire 9-item Depression scale