《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (3): 233-235.

• 论文 • 上一篇    下一篇

家兔佐剂性关节炎疼痛前后痛觉P300 的变化

卢惠苹1，张雷2   

  1. 1.福建省福州市第二医院康复科，福建医科大学康复治疗系，福建福州市 350007；2.南京军区福州总医院，福建福州市 350025。
  • 收稿日期:2011-09-05 修回日期:1900-01-01 出版日期:2012-03-25 发布日期:2012-03-25

Changes of Painful P300 in Rabbits with Adjuvant Induced Arthritis

LU Hui-ping, ZHANG Lei.   

  1. Department of Rehabilitation, Fuzhou 2nd Municipal Hospital; Department of Rehabilitation, Fujian Medical University, Fuzhou 350007, Fujian, China
  • Received:2011-09-05 Revised:1900-01-01 Published:2012-03-25 Online:2012-03-25

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摘要： 目的探讨家兔佐剂性关节炎疼痛前后痛觉诱发电位P300 成分的变化。方法分别记录10 只日本大耳白兔弗氏佐剂注射前及注射后第7 天、第21 天用吗啡止痛前后的痛觉P300 和痛阈。结果家兔注射佐剂后第7 天和第21 天痛阈明显下降(P<0.01)，痛觉P300 潜伏期明显缩短(P<0.01)；止痛后痛阈明显上升(P<0.01)，潜伏期明显延长(P<0.01)。注射佐剂后第7 天，P300 波幅较注射前增大(P<0.05)，止痛后波幅明显减小(P<0.01)；注射佐剂后第21 天波幅较第7 天明显减小(P<0.01)。痛阈与痛觉P300 潜伏期明显正相关(r=0.516, P<0.01)，与波幅无相关关系。结论佐剂性关节炎兔的痛觉P300 与疼痛程度密切相关。

关键词: 佐剂性关节炎, P300, 痛觉诱发电位, 波幅, 潜伏期, 痛阈

Abstract: Objective To explore the changes of the painful P300 under the state of pain induced by adjuvant induced arthritis (AIA) inrabbits. Methods The painful P300 and pain threshold in 10 rabbits were recorded before Freud's adjuvant injection, before and after morphineinjection on the 7th day and the 21st day after Freud's adjuvant injection. Results With the pain threshold lowed (P<0.01), the latencyof painful P300 was differentially shortened on the 7th day and 21st days after adjuvant injection (P<0.01). After morphine injected, painthreshold increased (P<0.01) and the latency of painful P300 was prolonged (P<0.01). On the 7th day, the amplitude of painful P300 differentiallyincreased (P<0.05), and decreased (P<0.01) after morphine injected. The amplitude of painful P300 on the 21st day was significantlylower than that of the 7th day (P<0.01). The pain threshold correlated with the latency of painful P300 (r=0.516, P<0.01). ConclusionPainful P300 is related with the condition of pain in rabbits with AIA.

Key words: adjuvant induced arthritis, P300, pain evoked potentials, amplitude, latency, pain threshold