《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (3): 280-282.

• 论文 • 上一篇    下一篇

非外伤性横纹肌溶解症的临床特点

王锁彬，贾建平   

  1. 首都医科大学宣武医院神经内科，北京市 100053。
  • 收稿日期:2011-06-22 修回日期:1900-01-01 出版日期:2012-03-25 发布日期:2012-03-25

Clinical Features of Non-traumatic Rhabdomyolysis: 11 Cases Report

WANG Suo-bin, JIA Jian-ping.   

  1. Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2011-06-22 Revised:1900-01-01 Published:2012-03-25 Online:2012-03-25

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摘要： 目的了解非外伤性横纹肌溶解症(RM)的临床特点和发病机制。方法对11 例非外伤性RM的病因和临床表现进行回顾性分析。结果本组病因包括药物性3 例，一氧化碳中毒2 例，高强度运动2 例，高强度农业劳动1 例，其他3 例。临床表现为肌无力、肌痛、肌肿胀、茶色尿、肾功能衰竭，实验室检验包括肌酸激酶增高，各种电解质紊乱。结论药物是引起非外伤性RM的主要原因，诊断主要依据临床表现和血清肌酸激酶显著升高。急性肾功能衰竭是其严重和导致死亡的主要并发症。

关键词: 横纹肌溶解症, 病因, 临床表现, 急性肾功能衰竭

Abstract: Objective To study the clinical features and pathogenesis of non-traumatic rhabdomyolysis (RM). Methods The causes andclinical features of 11 patients with non-traumatic RM were analyzed retrospectively. Results The causes of non-traumatic RM includeddrugs (3 cases), carbon monoxide poisoning (2 cases), intensive exercise training (2 cases), strenuous farming work (1 cases) and others (3cases). The clinical presentations included muscular weakness, myalgia, muscle swelling, pigmented urine and acute renal failure. The activityof serum creatine kinase increased, electrolyte derangements were common complications. Conclusion Prescribed drugs are the mostcommon cause of non-traumatic RM. The diagnosis of non-traumatic RM is chiefly based on clinical presentations and high levels of serumcreatine kinase. Acute renal failure is the most severe complication and cause of death.

Key words: rhabdomyolysis, etiology, clinical features, acute renal failure