《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (4): 329-330.

• 论文 • 上一篇    下一篇

莫诺苷对二磷酸腺苷诱导兔血小板聚集后血栓素B2的影响

左玮1,2，王晓锋2,3，艾厚喜2，张丽2，季晖1，陈乃宏3，王文2   

  1. 1.中国药科大学，江苏南京市 210009；2.首都医科大学宣武医院，北京市 100053；3.中国医学科学院药物所，北京市 100050。
  • 收稿日期:2011-08-05 修回日期:1900-01-01 出版日期:2012-04-25 发布日期:2012-04-25

Effects of Morroniside on Inhibiting Thromboxane B2 after Platelet Aggregation Induced by Adenosine Diphosphate in Rabbits

ZUO Wei, WANG Xiao-feng, AI Hou-xi, et al.   

  1. China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2011-08-05 Revised:1900-01-01 Published:2012-04-25 Online:2012-04-25

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摘要： 目的观察莫诺苷对二磷酸腺苷(ADP)诱导兔血小板聚集后血栓素(TX)B2含量的影响。方法利用酶联免疫吸附剂测定法(ELISA)试剂盒，检测不同条件下ADP 诱导血小板聚集后TXB2的含量。结果与对照组相比，莫诺苷能显著抑制由ADP 诱导兔血小板聚集后TXB2的升高(P<0.001)。结论莫诺苷可以不同程度抑制ADP 诱导兔血小板聚集后TXB2的生成。

关键词: 莫诺苷, 血小板聚集, 血栓素B2, 兔

Abstract: Objective To study the effects of morroniside on thromboxane B2 in the condition of platelet aggregation in rabbits inducedby adenosine diphosphate (ADP). Methods The level of TXB2 was determined by enzyme-linked immunosorbent assay (ELISA). ResultsCompared with the controls, morroniside significantly inhibited the increase of TXB2 induced by ADP (P<0.001). Conclusion Morronisidecan inhibit the level of TXB2 by inhibiting the platelet aggregation in rabbits induced by ADP.

Key words: morroniside, platelet aggregation, thromboxane B2, rabbits