《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (4): 331-332.

• 论文 • 上一篇    下一篇

莫诺苷对二磷酸腺苷诱导兔血小板聚集后环氧酶的影响

孙盼莉1,2，魏守蓉1，王晓锋2,3，王文2，陈乃宏3，薛存宽1，刘浩1   

  1. 1.华中科技大学同济医学院，湖北武汉市 430030；2.首都医科大学宣武医院，北京市 100053；3.中国医学科学院药物所，北京市 100050。
  • 收稿日期:2011-10-18 修回日期:1900-01-01 出版日期:2012-04-25 发布日期:2012-04-25

Effects of Morroniside on Cycloxygenase after Platelet Aggregation Induced by Adenosine Diphosphate in Rabbits

SUN Pan-li,WEI Shou-rong, WANG Xiao-feng, et al.   

  1. Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei,China
  • Received:2011-10-18 Revised:1900-01-01 Published:2012-04-25 Online:2012-04-25

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摘要： 目的研究莫诺苷对二磷酸腺苷(ADP)诱导兔血小板聚集后环氧酶(Cox)含量的影响。方法利用酶联免疫吸附剂测定法(ELISA)检测不同给药组间ADP 诱导体外分离的兔血小板聚集后Cox 的含量。结果与空白对照组相比，莫诺苷各剂量组均能显著降低ADP 诱导兔血小板聚集后Cox 的含量(P<0.001)，并具有较好的浓度依赖性，其中高剂量组抑制率达30%左右。结论莫诺苷可能通过影响Cox 的含量抑制ADP 诱导的兔血小板聚集。

关键词: 莫诺苷, 血小板聚集, 环氧酶, 兔

Abstract: Objective To investigate the effect of morroniside on cycloxygenase (Cox) in the condition of platelet aggregation inducedby adenosine diphosphate (ADP) in rabbits. Methods The levels of Cox induced by ADP in different groups were detected by enzyme-linked immunosorbent assay (ELISA). Results Compared with the control group, all the morroniside groups significantly inhibited theincrease of Cox induced by ADP (P<0.001), which had concentration dependence, and the inhibition rate of high dose group was 30%. ConclusionMorroniside can decrease the level of Cox and it may be the mechanism of morroniside on inhibiting the platelet aggregation inducedby ADP in rabbits.

Key words: morroniside, platelet aggregation, cycloxygenase, rabbits