《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (5): 476-477.

• 论文 • 上一篇    下一篇

帕利哌酮联合无抽搐电休克对难治性精神分裂患者认知功能的疗效

李耀东，唐立岩，宋志文，黄再萍   

  1. 广东顺德伍仲珮纪念医院，广东顺德区 528300。
  • 收稿日期:2012-02-10 修回日期:1900-01-01 出版日期:2012-05-25 发布日期:2012-05-25

Effects of Paliperidone Combined with Modified Electric Convulsive Therapy on Congnitive Function in Refractory Schizophrenics

LI Yao-dong, TANG Li-yan, SONG Zhi-wen, et al.   

  1. Shunde Wuzhongpei Hospital, Shunde 528300, Guangdong, China
  • Received:2012-02-10 Revised:1900-01-01 Published:2012-05-25 Online:2012-05-25

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摘要： 目的观察帕利哌酮联合无抽搐电休治疗(MECT)对难治精神分裂症患者认知功能的影响。方法30 例精神分裂症患者进行帕利哌酮联合MECT 治疗，治疗前后进行威斯康星卡片分类(WCST)、连线试验A和B、数字广度、数字符号和临床记忆量表(CMS)检测。结果治疗后，患者连线试验A、B 完成时间较治疗前缩短(P<0.05)，WCST 测试、数字符号、数字广度及CMS 治疗前后均无显著性差异。结论帕利哌酮联合MECT 治疗能改善难治性精神分裂症患者的记忆功能及注意力功能。

关键词: 难治性精神分裂症, 帕利哌酮, 无抽搐电休克, 认知功能

Abstract: Objective To investigate the effect of paliperidone extended-release combined with modified electric convulsive therapy(MECT) on cognitive function in patients with refractory schizophrenia. Methods 30 patients were reviewed with the Wisconsin Card SortingTest (WCST), the Trail Making Test A and B, Digit Span Test (DST), Digit Symbol Substitution Test (DSST) and the Clinical MemoryScale (CMS). Results The time shortened after treatment in the Trail Making Test A and B (P<0.05). There was no significant difference beforeand after the treatment in the other tests. Conclusion Paliperidone combined with modified electric convulsive therapy may inmprovethe memory and attention in schizophrenics.

Key words: refractory schizophrenia, paliperidone, modified electric convulsive therapy, cognitive function