《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (7): 645-646.

• 论文 • 上一篇    下一篇

老年脑卒中抑郁患者血清同型半胱氨酸水平观察

涂文军1,2，陈惠1,2，史晓东1,2，赵圣杰3   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院，北京市100068；3.上海交通大学附属第一人民医院，上海市200080。
  • 收稿日期:2011-04-14 修回日期:2012-03-28 出版日期:2012-07-25 发布日期:2012-07-25
  • 通讯作者: 陈惠

Relationship between Serum Homocysteine and Post-stroke Depression in Elderly

TU Wen-jun, CHEN Hui, SHI Xiao-dong, et al   

  1. Capital Medical University School of Rehabilitation Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2011-04-14 Revised:2012-03-28 Published:2012-07-25 Online:2012-07-25

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摘要： 目的讨论老年脑卒中后抑郁患者血清同型半胱氨酸水平与抑郁的关系。方法62 例脑卒中后抑郁老年患者以及20例脑卒中后无抑郁老年患者采用荧光偏振免疫分析(FPIA)检测同型半胱氨酸。100 例老年健康体检者作为对照组。结果卒中后抑郁组、卒中后非抑郁组、对照组血清同型半胱氨酸水平分别为(25.59±9.47) μmol/L、(18.56±7.84) μmol/L、(12.67±6.45) μmol/L，两两比较均存在显著性差异(P<0.05)。在卒中后抑郁组，血清同型半胱氨酸水平与汉密尔顿抑郁量表评分(r=0.8953, P<0.05)、年龄(r=0.8462, P<0.05)均相关。结论脑卒中后血清同型半胱氨酸水平与抑郁发病相关。

关键词: 卒中后抑郁, 老年, 同型半胱氨酸

Abstract: Objective To investigate the relationship between serum homocysteine and post-stroke depression in elderly. Methods 62 elderly first stroke patients with post-stroke depression, 20 first stroke patients without depression, and 100 healthy elderly as control were detected their fasting serum homocysteine with fluorescence polarization immunoassay. Results Serum homocysteine were (25.59±9.47) μmol/ L, (18.56±7.84) μmol/L, and (12.67±6.45) μmol/L in the depression group, non depression group and healthy group, respectively (P<0.05). The level of homocysteine correlated with the score of Hamilton Depression Scale (r=0.8953, P<0.05) and age (r=0.8462, P<0.05). Conclusion The level of serum homocyteine might be one of risk factor of depression in patients with stroke.

Key words: post-stroke depression, elderly, homocysteine